中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
首页 机构 成果 学者
  
  1. CAS IR Grid
  2. 昆明植物研究所
  3. 中国科学院昆明植物研究所
  4. 植物化学与西部植物资源持续利用国家重点实验室
Metabolic Activation of Myristicin and Its Role in Cellular Toxicity

文献类型：期刊论文

作者Zhu, Xu1,2; Wang, Yi-Kun1,2; Yang, Xiao-Nan1,3; Xiao, Xue-Rong1; Zhang, Ting1,2; Yang, Xiu-Wei4; Qin, Hong-Bo1; Li, Fei1,5
刊名JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
出版日期2019-04-17
卷号67期号:15页码:4328-4336
关键词myristicin 1 '-hydroxymyristicin metabolic activation metabolomics
ISSN号0021-8561
DOI10.1021/acs.jafc.9b00893
通讯作者Qin, Hong-Bo(qinhongbo@mail.kib.ac.cn) ; Li, Fei(lifeib@mail.kib.ac.cn)
英文摘要Myristicin is widely distributed in spices and medicinal plants. The aim of this study was to explore the role of metabolic activation of myristicin in its potential toxicity through a metabolomic approach. The myristicin-N-acetylcysteine adduct was identified by comparing the metabolic maps of myristicin and 1'-hydroxymyristicin. The supplement of N-acetylcysteine could protect against the cytotoxicity of myristicin and 1'-hydroxymyristicin in primary mouse hepatocytes. When the depletion of intracellular N-acetylcysteine was pretreated with diethyl maleate in hepatocytes, the cytotoxicity induced by myristicin and 1'-hydroxymyristicin was deteriorated. It suggested that the N-acetylcysteine adduct resulting from myristicin bioactivation was closely associated with myristicin toxicity. Screening of human recombinant cytochrome P450s (CYPs) and treatment with CYP inhibitors revealed that CYP1A1 was mainly involved in the formation of 1'-hydroxymyristicin. Collectively, this study provided a global view of myristicin metabolism and identified the N-acetylcysteine adduct resulting from myristicin bioactivation, which could be used for understanding the mechanism of myristicin toxicity.
WOS研究方向Agriculture ; Chemistry ; Food Science & Technology
语种英语
WOS记录号WOS:000465189400022
源URL[http://ir.kib.ac.cn/handle/151853/66348]  
专题昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室
通讯作者Qin, Hong-Bo; Li, Fei
作者单位1.Chinese Acad Sci, Kunming Inst Bot, States Key Lab Phytochem & Plant Resources West C, Kunming 650201, Yunnan, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Guangxi Bot Garden Med Plant, Guangxi Key Lab Med Resources Protect & Genet Imp, Nanning 530023, Guangxi, Peoples R China
4.Peking Univ, Sch Pharmaceut Sci, Hlth Sci Ctr, Beijing 100191, Peoples R China
5.Jiangxi Univ Tradit Chinese Med, Nanchang 330004, Jiangxi, Peoples R China
推荐引用方式
GB/T 7714		 Zhu, Xu,Wang, Yi-Kun,Yang, Xiao-Nan,et al. Metabolic Activation of Myristicin and Its Role in Cellular Toxicity[J]. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,2019,67(15):4328-4336.
APA Zhu, Xu.,Wang, Yi-Kun.,Yang, Xiao-Nan.,Xiao, Xue-Rong.,Zhang, Ting.,...&Li, Fei.(2019).Metabolic Activation of Myristicin and Its Role in Cellular Toxicity.JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,67(15),4328-4336.
MLA Zhu, Xu,et al."Metabolic Activation of Myristicin and Its Role in Cellular Toxicity".JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 67.15(2019):4328-4336.

入库方式： OAI收割

来源：昆明植物研究所

浏览0
下载0
收藏0
其他版本

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。