(+/-) Cochlearoids N-P: three pairs of phenolic meroterpenoids from the fungus Ganoderma cochlear and their bioactivities
文献类型：期刊论文
| 作者 | Qin, Fu-Ying1,2; Yan, Yong-Ming3; Tu, Zheng-Chao4; Cheng, Yong-Xian1,2,3 |
| 刊名 | JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
 |
| 出版日期 | 2019-06-03 |
| 卷号 | 21期号:6页码:542-550 |
| 关键词 | Ganoderma cochlear meroterpenoids BRD4 cytotoxic activity antibacterial activity |
| ISSN号 | 1028-6020 |
| DOI | 10.1080/10286020.2018.1481052 |
| 通讯作者 | Cheng, Yong-Xian(yxcheng@szu.edu.cn) |
| 英文摘要 | Three pairs of meroterpenoids (+/-) cochlearoids N-P (1-3) were isolated from the fruiting bodies of Ganoderma cochlear. Their structures including absolute configurations were assigned by spectroscopic techniques. All the isolated compounds were tested for their inhibitory activities toward BRD4, human cancer cells, and micro-organisms. The results show that the enantiomers of (+/-)-1 are BRD4 inhibitors, (-)-1 and (+)-3 are cytotoxic against human cancer cells (K562) with IC50 values of 7.68 and 6.68 mu M, respectively. Besides compounds (+/-)-2 and (+/-)-3 exhibit potent inhibitory activity against Staphylococcus aureus with IC50 values in the range of 5.43-17.99 mu M. [GRAPHICS] . |
| WOS研究方向 | Plant Sciences ; Chemistry ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000467401800007 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/66881]  |
| 专题 | 昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室 |
| 通讯作者 | Cheng, Yong-Xian |
| 作者单位 | 1.Henan Univ Chinese Med, Sch Pharm, Zhengzhou 450008, Henan, Peoples R China 2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 3.Shenzhen Univ, Hlth Sci Ctr, Sch Pharmaceut Sci, Sch Med,Guangdong Key Lab Genome Stabil & Dis Pre, Shenzhen 518060, Peoples R China 4.Chinese Acad Sci, Guangzhou Inst Biomed & Hlth, Guangzhou 510530, Guangdong, Peoples R China |
| 推荐引用方式 GB/T 7714 | Qin, Fu-Ying,Yan, Yong-Ming,Tu, Zheng-Chao,et al. (+/-) Cochlearoids N-P: three pairs of phenolic meroterpenoids from the fungus Ganoderma cochlear and their bioactivities[J]. JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH,2019,21(6):542-550. |
| APA | Qin, Fu-Ying,Yan, Yong-Ming,Tu, Zheng-Chao,&Cheng, Yong-Xian.(2019).(+/-) Cochlearoids N-P: three pairs of phenolic meroterpenoids from the fungus Ganoderma cochlear and their bioactivities.JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH,21(6),542-550. |
| MLA | Qin, Fu-Ying,et al."(+/-) Cochlearoids N-P: three pairs of phenolic meroterpenoids from the fungus Ganoderma cochlear and their bioactivities".JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH 21.6(2019):542-550. |
入库方式： OAI收割
来源：昆明植物研究所
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