Structurally diverse diterpenoids from Isodon ternifolius collected from three regions
文献类型：期刊论文
| 作者 | Gou, Lei-Lei1,2; Hu, Kun1 ; Yang, Qian1; Li, Xiao-Nian1; Sun, Han-Dong1; Xiang, Chun-Lei3; Puno, Pema-Tenzin1
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| 刊名 | TETRAHEDRON
 |
| 出版日期 | 2019-05-10 |
| 卷号 | 75期号:19页码:2797-2806 |
| 关键词 | Isodon ternifolius Diterpenoids Cytotoxic activity NMR computation ECD calculation |
| ISSN号 | 0040-4020 |
| DOI | 10.1016/j.tet.2019.03.056 |
| 通讯作者 | Xiang, Chun-Lei(xiangchunlei@mail.kib.ac.cn) ; Puno, Pema-Tenzin(punopematenzin@mail.kib.ac.cn) |
| 英文摘要 | Phytochemical investigation of the aerial parts of Isodon ternifolius from three regions in Yunnan Province afforded 9 new diterpenoids, ternifoliusins A-1 (1-9), together with 26 known diterpenoids. Among them, ternifoliusins A-D possess rare 6,7:8,15-diseco-7,20-olide-6,8-cyclo-ent-kaurane diterpenoid scaffold. The structures of all compounds were determined by comprehensive spectroscopic analysis, as well as quantum chemical calculation methods. Moreover, the molecular constitutions and configurations of ternifoliusins A, E, and F (I, 5, 6) were confirmed by single-crystal X-ray diffraction analysis. Ten compounds were assayed for their cytotoxic activity against the HL-60, SMMC-7721, A-549, MCF-7, and SW-480 human tumor cell lines, and compounds 13, 17, 19, 20, 31 and 34 were demonstrated to be active against all of the five human tumor cell lines. (C) 2019 Elsevier Ltd. All rights reserved. |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000467510100006 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/66908]  |
| 专题 | 昆明植物研究所_中国科学院东亚植物多样性与生物地理学重点实验室 |
| 通讯作者 | Xiang, Chun-Lei; Puno, Pema-Tenzin |
| 作者单位 | 1.Chinese Acad Sci, Yunnan Key Lab Nat Med Chem, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Chinese Acad Sci, Kunming Inst Bot, CAS Key Lab Plant Div & Biogeog East Asia, Kunming 650201, Yunnan, Peoples R China |
| 推荐引用方式 GB/T 7714 | Gou, Lei-Lei,Hu, Kun,Yang, Qian,et al. Structurally diverse diterpenoids from Isodon ternifolius collected from three regions[J]. TETRAHEDRON,2019,75(19):2797-2806. |
| APA | Gou, Lei-Lei.,Hu, Kun.,Yang, Qian.,Li, Xiao-Nian.,Sun, Han-Dong.,...&Puno, Pema-Tenzin.(2019).Structurally diverse diterpenoids from Isodon ternifolius collected from three regions.TETRAHEDRON,75(19),2797-2806. |
| MLA | Gou, Lei-Lei,et al."Structurally diverse diterpenoids from Isodon ternifolius collected from three regions".TETRAHEDRON 75.19(2019):2797-2806. |
入库方式： OAI收割
来源：昆明植物研究所
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