Physicochemical Characteristics and Anticoagulant Activities of the Polysaccharides from Sea Cucumber Pattalus mollis
文献类型：期刊论文
| 作者 | Zheng, Wenqi1; Zhou, Lutan2,3; Lin, Lisha2,3; Cai, Ying2,3; Sun, Huifang2,3; Zhao, Longyan1 ; Gao, Na1; Yin, Ronghua2; Zhao, Jinhua1,2
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| 刊名 | MARINE DRUGS
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| 出版日期 | 2019-04-01 |
| 卷号 | 17期号:4页码:15 |
| 关键词 | Pattalus mollis fucosylated glycosaminoglycan fucan sulfate physicochemical characteristics anticoagulant activities |
| ISSN号 | 1660-3397 |
| DOI | 10.3390/md17040198 |
| 通讯作者 | Yin, Ronghua(yinronghua@mail.kib.ac.cn) ; Zhao, Jinhua(zhao.jinhua@yahoo.com) |
| 英文摘要 | Sulfated polysaccharides from sea cucumbers possess distinct chemical structure and various biological activities. Herein, three types of polysaccharides were isolated and purified from Pattalus mollis, and their structures and bioactivities were analyzed. The fucosylated glycosaminoglycan (PmFG) had a CS-like backbone composed of the repeating units of {-4-d-GlcA--1,3-d-GalNAc(4S6S)--1-}, and branches of a sulfated -l-Fuc (including Fuc(2S4S), Fuc(3S4S) and Fuc(4S) with a molar ratio of 2:2.5:1) linked to O-3 of each d-GlcA. The fucan sulfate (PmFS) had a backbone consisting of a repetitively linked unit {-4-l-Fuc(2S)--1-}, and interestingly, every trisaccharide unit in its backbone was branched with a sulfated -l-Fuc (Fuc(4S) or Fuc(3S) with a molar ratio of 4:1). Apart from the sulfated polysaccharides, two neutral glycans (PmNG-1 & -2) differing in molecular weight were also obtained and their structures were similar to animal glycogen. Anticoagulant assays indicated that PmFG and PmFS possessed strong APTT prolonging and intrinsic factor Xase inhibition activities, and the sulfated -l-Fuc branches might contribute to the anticoagulant and anti-FXase activities of both PmFG and PmFS. |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000467307100005 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/66911]  |
| 专题 | 昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室 |
| 通讯作者 | Yin, Ronghua; Zhao, Jinhua |
| 作者单位 | 1.South Cent Univ Nationalities, Sch Pharmaceut Sci, Wuhan 430074, Hubei, Peoples R China 2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zheng, Wenqi,Zhou, Lutan,Lin, Lisha,et al. Physicochemical Characteristics and Anticoagulant Activities of the Polysaccharides from Sea Cucumber Pattalus mollis[J]. MARINE DRUGS,2019,17(4):15. |
| APA | Zheng, Wenqi.,Zhou, Lutan.,Lin, Lisha.,Cai, Ying.,Sun, Huifang.,...&Zhao, Jinhua.(2019).Physicochemical Characteristics and Anticoagulant Activities of the Polysaccharides from Sea Cucumber Pattalus mollis.MARINE DRUGS,17(4),15. |
| MLA | Zheng, Wenqi,et al."Physicochemical Characteristics and Anticoagulant Activities of the Polysaccharides from Sea Cucumber Pattalus mollis".MARINE DRUGS 17.4(2019):15. |
入库方式： OAI收割
来源：昆明植物研究所
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