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Identification of Functional Gene Modules Associated With STAT-Mediated Antiviral Responses to White Spot Syndrome Virus in Shrimp

文献类型：期刊论文

作者Zhu, Guanghui1,2; Li, Shihao3,4,5; Wu, Jun2; Li, Fuhua3,4,5; Zhao, Xing-Ming1
刊名FRONTIERS IN PHYSIOLOGY
出版日期2019-03-11
卷号10页码:9
关键词antivirus response co-expression network gene module STAT dsRNA white spot syndrome virus shrimp
ISSN号1664-042X
DOI10.3389/fphys.2019.00212
通讯作者Li, Fuhua(fhli@qdio.ac.cn) ; Zhao, Xing-Ming(xmzhao@fudan.edu.cn)
英文摘要White spot syndrome virus (WSSV) is one of the major threats to shrimp aquaculture. It has been found that the signal transducer and activator of transcription (STAT) protein plays an important role in the antiviral immunity of shrimp with a WSSV infection. However, the mechanism that underlies the STAT-mediated antiviral responses in shrimp, against WSSV infection, remains unclear. In this work, based on the gene expression profiles of shrimp with an injection of WSSV and STAT double strand RNA (dsRNA), we constructed a gene co-expression network for shrimp and identified the gene modules that are possibly responsible for STAT-mediated antiviral responses. These gene modules are found enriched in the regulation of the viral process, JAK-STAT cascade and the regulation of immune effector process pathways. The gene modules identified here provide insights into the molecular mechanism that underlies the STAT-mediated antiviral response of shrimp, against WSSV.
资助项目National Natural Science Foundation of China[61772368] ; National Natural Science Foundation of China[61572363] ; National Natural Science Foundation of China[91530321] ; Natural Science Foundation of Shanghai[17ZR1445600] ; Open Fund of Laboratory for Marine Biology and Biotechnology, Qingdao National Laboratory for Marine Science and Technology, Qingdao, China[OF2015NO13]
WOS研究方向Physiology
语种英语
WOS记录号WOS:000460860100001
出版者FRONTIERS MEDIA SA
源URL[http://ir.qdio.ac.cn/handle/337002/155262]  
专题海洋研究所_实验海洋生物学重点实验室
通讯作者Li, Fuhua; Zhao, Xing-Ming
作者单位1.Fudan Univ, Inst Sci & Technol Brain Inspired Intelligence, Shanghai, Peoples R China
2.Tongji Univ, Dept Comp Sci & Technol, Shanghai, Peoples R China
3.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao, Peoples R China
4.Chinese Acad Sci, Inst Oceanol, Qingdao, Peoples R China
5.Chinese Acad Sci, Ctr Ocean Mega Sci, Qingdao, Peoples R China
推荐引用方式
GB/T 7714		 Zhu, Guanghui,Li, Shihao,Wu, Jun,et al. Identification of Functional Gene Modules Associated With STAT-Mediated Antiviral Responses to White Spot Syndrome Virus in Shrimp[J]. FRONTIERS IN PHYSIOLOGY,2019,10:9.
APA Zhu, Guanghui,Li, Shihao,Wu, Jun,Li, Fuhua,&Zhao, Xing-Ming.(2019).Identification of Functional Gene Modules Associated With STAT-Mediated Antiviral Responses to White Spot Syndrome Virus in Shrimp.FRONTIERS IN PHYSIOLOGY,10,9.
MLA Zhu, Guanghui,et al."Identification of Functional Gene Modules Associated With STAT-Mediated Antiviral Responses to White Spot Syndrome Virus in Shrimp".FRONTIERS IN PHYSIOLOGY 10(2019):9.

入库方式： OAI收割

来源：海洋研究所

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