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Phytochemical and chemotaxonomic study on Leathesia nana (Chordariaceae)

文献类型：期刊论文

作者Xu, Kuo1,2; Guo, Shuju1,2; Jia, Xiaoling1,2; Li, Xiang4; Shi, Dayong1,2,3
刊名BIOCHEMICAL SYSTEMATICS AND ECOLOGY
出版日期2018-12-01
卷号81页码:42-44
ISSN号0305-1978
关键词Leathesia nana Chordariaceae Bromophenol Chemotaxonomy PTP1B
DOI10.1016/j.bse.2018.08.002
通讯作者Shi, Dayong(shidayong@qdio.ac.cn)
英文摘要A phytochemical study on whole Leathesia nana plants led to isolation of 22 compounds, including 12 bromophenols (1-12), 1 megastigmane sesquiterpene (13), 4 monoindole alkaloids (14-17), and 5 other small mond lecules (18-22). Their structures were elucidated by H-1 and C-13 NMR spectroscopy, HRESIMS data, and by comparison with closely related compounds published previously. Compounds 8-11, 13, 14, and 17-22 were first reported from Leathesia nana, while 1-7, 12, 15, and 16 had been previously isolated, which could be considered chemotaxonomic markers. In addition, the biological activities of all of the compounds were evaluated with protein tyrosine phosphatase 1b (PTP1B). Compounds 1-3 and 5-7 exhibited potent inhibitory effects on PTP1B with IC50 values of 9.40, 4.30, 7.94, 14.64, 16.40, and 10.95 mu M, respectively, while the other compounds showed no obvious activities (IC50 values > 20 mu M.
资助项目National Natural Science Foundation of China[81803375] ; National Postdoctoral Program for Innovative Talents[BX201700247] ; China Postdoctoral Science Foundation[2018M630804] ; Natural Science Foundation of Shandong Province[ZR2016DQ07] ; Shandong Provincial Natural Science Foundation for Distinguished Young Scholars[JQ201722]
WOS研究方向Biochemistry & Molecular Biology ; Environmental Sciences & Ecology ; Evolutionary Biology
语种英语
出版者PERGAMON-ELSEVIER SCIENCE LTD
WOS记录号WOS:000452565100009
源URL[http://ir.qdio.ac.cn/handle/337002/155805]  
专题海洋研究所_实验海洋生物学重点实验室
通讯作者Shi, Dayong
作者单位1.Chinese Acad Sci, Inst Oceanol, CAS Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China
2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Drugs & Bioprod, Qingdao 266237, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
4.Ocean Univ China, Coll Marine Life Sci, Qingdao 266100, Peoples R China
推荐引用方式
GB/T 7714		 Xu, Kuo,Guo, Shuju,Jia, Xiaoling,et al. Phytochemical and chemotaxonomic study on Leathesia nana (Chordariaceae)[J]. BIOCHEMICAL SYSTEMATICS AND ECOLOGY,2018,81:42-44.
APA Xu, Kuo,Guo, Shuju,Jia, Xiaoling,Li, Xiang,&Shi, Dayong.(2018).Phytochemical and chemotaxonomic study on Leathesia nana (Chordariaceae).BIOCHEMICAL SYSTEMATICS AND ECOLOGY,81,42-44.
MLA Xu, Kuo,et al."Phytochemical and chemotaxonomic study on Leathesia nana (Chordariaceae)".BIOCHEMICAL SYSTEMATICS AND ECOLOGY 81(2018):42-44.

入库方式： OAI收割

来源：海洋研究所

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