Two New Diphenylketones and a New Xanthone from Talaromyces islandicus EN-501, an Endophytic Fungus Derived from the Marine Red Alga Laurencia okamurai
文献类型：期刊论文
| 作者 | Li, Hong-Lei1,2 ; Li, Xiao-Ming1; Liu, Hui1,2; Meng, Ling-Hong1; Wang, Bin-Gui1
|
| 刊名 | MARINE DRUGS
 |
| 出版日期 | 2016-12-01 |
| 卷号 | 14期号:12页码:8 |
| 关键词 | Laurencia okamurai Talaromyces islandicus diphenylketone xanthone antioxidative activity antibacterial activity |
| ISSN号 | 1660-3397 |
| DOI | 10.3390/md14120223 |
| 通讯作者 | Meng, Ling-Hong(menglh@ms.qdio.ac.cn) ; Wang, Bin-Gui(wangbg@ms.qdio.ac.cn) |
| 英文摘要 | Two new diphenylketones (1 and 2), a new xanthone (3), and a known xanthone analogue (4) were isolated and identified from Talaromyces islandicus EN-501, an endophytic fungus obtained from the fresh collected marine red alga Laurencia okamurai. Their structures were elucidated on the basis of NMR spectroscopic and X-ray crystallographic analysis. The joint isolation of benzophenones and xanthones from the same fungal strain supports the biogenesis of xanthones via a benzophenone intermediate. It is worth mentioning that xanthones 3 and 4 have a methyl group at C-6 and C-2, respectively, which is uncommon compared with typical xanthones usually having a methyl group at C-8. Compounds 1-4 exhibited potent antioxidative activities against DPPH (1,1-diphenyl-2-picrylhydrazyl) and ABTS (2,2-azino-bis(3-ethylbenzothiazoline-6-sulphonate) radicals with IC50 values ranging from 0.58 to 6.92 g/mL, which are stronger than that of the positive controls BHT (butylated hydroxytoluene) and ascorbic acid. Compounds 1, 3, and 4 also showed inhibitory activities against several pathogenic bacteria. |
| 资助项目 | National Natural Science Foundation of China[31330009] ; Scientific and Technological Innovation Project of Qingdao National Laboratory for Marine Science and Technology[2015ASKJ02] ; Taishan Scholar Project from Shandong Province |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000392486100007 |
| 出版者 | MDPI AG |
| 源URL | [http://ir.qdio.ac.cn/handle/337002/157263]  |
| 专题 | 海洋研究所_实验海洋生物学重点实验室 |
| 通讯作者 | Meng, Ling-Hong; Wang, Bin-Gui |
| 作者单位 | 1.Chinese Acad Sci, Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Key Lab Expt Marine Biol,Inst Oceanol, Nanhai Rd 7, Qingdao 266071, Peoples R China 2.Univ Chinese Acad Sci, Yuquan Rd 19A, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Hong-Lei,Li, Xiao-Ming,Liu, Hui,et al. Two New Diphenylketones and a New Xanthone from Talaromyces islandicus EN-501, an Endophytic Fungus Derived from the Marine Red Alga Laurencia okamurai[J]. MARINE DRUGS,2016,14(12):8. |
| APA | Li, Hong-Lei,Li, Xiao-Ming,Liu, Hui,Meng, Ling-Hong,&Wang, Bin-Gui.(2016).Two New Diphenylketones and a New Xanthone from Talaromyces islandicus EN-501, an Endophytic Fungus Derived from the Marine Red Alga Laurencia okamurai.MARINE DRUGS,14(12),8. |
| MLA | Li, Hong-Lei,et al."Two New Diphenylketones and a New Xanthone from Talaromyces islandicus EN-501, an Endophytic Fungus Derived from the Marine Red Alga Laurencia okamurai".MARINE DRUGS 14.12(2016):8. |
入库方式： OAI收割
来源：海洋研究所
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