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Targeted and Multifunctional Technology for Identification between Hepatocellular Carcinoma and Liver Cirrhosis

文献类型：期刊论文

作者Deng, Han1,2,4; Shang, Wenting2; Lu, Guanhua1,2; Guo, Pengyu2; Ai, Ting1,2,4; Fang, Chihua1,4; Tian, Jie2,3
刊名ACS APPLIED MATERIALS & INTERFACES
出版日期2019-04-24
卷号11期号:16页码:14526-14537
关键词small hepatocellular carcinoma liver cirrhosis differential diagnosis photoacoustic imaging GPC3 photothermal therapy
ISSN号1944-8244
DOI10.1021/acsami.8b20600
通讯作者Fang, Chihua(fangch_dr@163.com) ; Tian, Jie(jie.tian@ia.ac.cn)
英文摘要Continuously updated diagnostic methods and advanced imaging methods have led to an increase in the early detection rate of small liver cancer; however, even with current diagnosis methods, it is still challenging to accurately judge a nodule with a diameter less than 2 cm whether it is hepatocellular carcinoma or liver cirrhosis. To solve this issue, a new technology is needed to distinguish above two kinds of liver nodules. There is an emerging imaging method that improves tissue resolution and sensitivity to detect micronodules with diameters less than 2 cm. To detect micronodules, photoacoustic imaging was used to provide noninvasive images at depths of several centimeters with a resolution of approximately 100 mu m. To improve specificity, we developed a probe that specifically targets hepatocellular carcinoma by recognizing the biomarker GPC3 on the hepatocellular carcinoma cell membrane. The probe not only has a strong photoacoustic signal but also has a magnetic resonance signal. Furthermore, the material owns photothermal effect that absorbs longer wavelength light and releases heat that effectively and accurately kills tumor cells, thus improving patient's survival and postoperative quality of life. Herein, we present a new technology that uses photoacoustic imaging to image and target microhepatocellular carcinoma biological processes derived from liver cirrhosis with high spatial resolution.
WOS关键词PHOTOACOUSTIC TOMOGRAPHY ; GLYPICAN-3 ; RECURRENCE ; STRATEGY ; CT ; EXPRESSION ; MANAGEMENT ; RESECTION ; THERAPY ; MARKER
资助项目Major Instrument Project of the National Natural Science Fund[81627805] ; National Key R&D Program of China[2017YFA0205200] ; National Natural Science Foundation of China[81601576] ; National Natural Science Foundation of China[81501540] ; National Natural Science Foundation of China[81227901] ; National Natural Science Foundation of China[61231004] ; National Natural Science Foundation of China[61671449] ; National Natural Science Foundation of China[81401471] ; National Natural Science Foundation of China[81527805] ; National Natural Science Foundation of China[U1401254] ; NSFC-GD Union Foundation[U1401254] ; Science and Technology Plan Project of Guangzhou[201604020144] ; Digital Theranostic Equipment Research Special Program of the 13th five-year National Key Research Plan[2016YFC0106500] ; Government of Guangdong Province[U1401254]
WOS研究方向Science & Technology - Other Topics ; Materials Science
语种英语
WOS记录号WOS:000466052800004
出版者AMER CHEMICAL SOC
资助机构Major Instrument Project of the National Natural Science Fund ; National Key R&D Program of China ; National Natural Science Foundation of China ; NSFC-GD Union Foundation ; Science and Technology Plan Project of Guangzhou ; Digital Theranostic Equipment Research Special Program of the 13th five-year National Key Research Plan ; Government of Guangdong Province
源URL[http://ir.ia.ac.cn/handle/173211/24185]  
专题自动化研究所_中国科学院分子影像重点实验室
通讯作者Fang, Chihua; Tian, Jie
作者单位1.Southern Med Univ, Zhujiang Hosp, Dept Hepatobiliary Surg, Guangzhou 510280, Guangdong, Peoples R China
2.Chinese Acad Sci, Inst Automat, CAS Key Lab Mol Imaging, Beijing 100190, Peoples R China
3.Beihang Univ, Beijing 100080, Peoples R China
4.Prov Clin & Engn Ctr Digital Med, Guangzhou 510280, Guangdong, Peoples R China
推荐引用方式
GB/T 7714		 Deng, Han,Shang, Wenting,Lu, Guanhua,et al. Targeted and Multifunctional Technology for Identification between Hepatocellular Carcinoma and Liver Cirrhosis[J]. ACS APPLIED MATERIALS & INTERFACES,2019,11(16):14526-14537.
APA Deng, Han.,Shang, Wenting.,Lu, Guanhua.,Guo, Pengyu.,Ai, Ting.,...&Tian, Jie.(2019).Targeted and Multifunctional Technology for Identification between Hepatocellular Carcinoma and Liver Cirrhosis.ACS APPLIED MATERIALS & INTERFACES,11(16),14526-14537.
MLA Deng, Han,et al."Targeted and Multifunctional Technology for Identification between Hepatocellular Carcinoma and Liver Cirrhosis".ACS APPLIED MATERIALS & INTERFACES 11.16(2019):14526-14537.

入库方式： OAI收割

来源：自动化研究所

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