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Microwave Responsive Nanoplatform via P-Selectin Mediated Drug Delivery for Treatment of Hepatocellular Carcinoma with Distant Metastasis

文献类型：期刊论文

作者Xu, Jinshun1,2,3; Chen, Xueqing5; Tan, Longfei2; Fu, Changhui2; Ahmed, Muneeb4; Tian, Jie6; Dou, Jianping1; Zhou, Qunfang1; Ren, Xiangling2; Wu, Qiong2
刊名NANO LETTERS
出版日期2019-05-01
卷号19期号:5页码:2914-2927
ISSN号1530-6984
关键词Nanoplatform P-selectin microwave hepatocellular carcinoma metastasis
DOI10.1021/acs.nanolett.8b05202
通讯作者Meng, Xianwei(mengxw@mail.ipc.ac.cn) ; Yu, Jie(yu-jie301@hotmail.com) ; Liang, Ping(liangping301@hotmail.com)
英文摘要Hepatocellular carcinoma (HCC) with metastatic disease is associated with a low survival in clinical practice. Many curative options including liver resection, transplantation, and thermal ablation are effective in local but limited for patients with distant metastasis. In this study, the efficacy, specificity, and safety of P-selectin targeted delivery and microwave (MW) responsive drug release is investigated for development of HCC therapy. By encapsulating doxorubicin (DOX) and MW sensitizer (1-butyl-3-methylimidazolium-L-lactate, BML) into fucoidan conjugated liposomal nanoparticles (TBP@DOX), specific accumulation and prominent release of DOX in orthotopic HCC and lung metastasis are achieved with adjuvant MW exposure. This results in orthotopic HCC growth inhibition that is not only 1.95-fold higher than found for nontargeted BP@DOX and 1.6-fold higher than nonstimuli responsive TP@DOX but is also equivalent to treatment with free DOX at a 10-fold higher dose. Furthermore, the optimum anticancer efficacy against distant lung metastasis and effective prevention of widespread dissemination with a prolonged survival is described. In addition, no adverse metabolic events are identified using the TBP@DOX nanodelivery system despite these events being commonly observed with traditional DOX chemotherapy. Therefore, administering TBP@DOX with MW exposure could potentially enhance the therapeutic efficacy of thermal-chemotherapy of HCC, especially those in the advanced stages.
WOS关键词CANCER STATISTICS ; TUMOR ; NANOPARTICLES ; NANOCARRIERS ; STRATEGIES ; SORAFENIB ; PLATFORM ; THERAPY ; LIGANDS
资助项目National Key R&D Program of China[2017YFC0112000] ; National Natural Science Foundation of China (NSFC)[81627803] ; National Natural Science Foundation of China (NSFC)[91859201] ; National Natural Science Foundation of China (NSFC)[81622024] ; National Natural Science Foundation of China (NSFC)[81701797] ; Beijing Natural Science Foundation[JQ18021] ; Beijing Natural Science Foundation[7192200] ; Beijing Natural Science Foundation[4161003]
WOS研究方向Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
语种英语
出版者AMER CHEMICAL SOC
WOS记录号WOS:000467781900020
资助机构National Key R&D Program of China ; National Natural Science Foundation of China (NSFC) ; Beijing Natural Science Foundation
源URL[http://ir.ia.ac.cn/handle/173211/24203]  
专题自动化研究所_中国科学院分子影像重点实验室
通讯作者Meng, Xianwei; Yu, Jie; Liang, Ping
作者单位1.Chinese Peoples Liberat Army Gen Hosp, Dept Intervent Ultrasound, Beijing 100853, Peoples R China
2.Chinese Acad Sci, Tech Inst Phys & Chem, CAS Key Lab Cryogen, Beijing 100190, Peoples R China
3.Chinese Peoples Liberat Army Gen Hosp, State Key Lab Kidney Dis, Beijing 100853, Peoples R China
4.Harvard Med Sch, Beth Israel Deaconess Med Ctr, Dept Radiol, Lab Minimally Invas Tumor Therapies, Boston, MA 02215 USA
5.Sichuan Prov Canc Hosp, Dept Ultrasound, Chengdu 610041, Peoples R China
6.Chinese Acad Sci, Inst Automat, CAS Key Lab Mol Imaging, Beijing 100190, Peoples R China
推荐引用方式
GB/T 7714		 Xu, Jinshun,Chen, Xueqing,Tan, Longfei,et al. Microwave Responsive Nanoplatform via P-Selectin Mediated Drug Delivery for Treatment of Hepatocellular Carcinoma with Distant Metastasis[J]. NANO LETTERS,2019,19(5):2914-2927.
APA Xu, Jinshun.,Chen, Xueqing.,Tan, Longfei.,Fu, Changhui.,Ahmed, Muneeb.,...&Liang, Ping.(2019).Microwave Responsive Nanoplatform via P-Selectin Mediated Drug Delivery for Treatment of Hepatocellular Carcinoma with Distant Metastasis.NANO LETTERS,19(5),2914-2927.
MLA Xu, Jinshun,et al."Microwave Responsive Nanoplatform via P-Selectin Mediated Drug Delivery for Treatment of Hepatocellular Carcinoma with Distant Metastasis".NANO LETTERS 19.5(2019):2914-2927.

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来源：自动化研究所

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