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Hypoxia-active nanoparticles used in tumor theranostic

文献类型：期刊论文

作者Wang, Yaqin1,2; Shang, Wenting2; Niu, Meng1; Tian, Jie2,3; Xu, Ke1
刊名INTERNATIONAL JOURNAL OF NANOMEDICINE
出版日期2019
卷号14页码:3705-3722
ISSN号1178-2013
关键词prodrug tumor microenvironment metal complex bioreductive
DOI10.2147/IJN.S196959
通讯作者Tian, Jie(jie.tian@ia.ac.cn) ; Xu, Ke(kexu@sina.vip.com)
英文摘要Hypoxia is a hallmark of malignant tumors and often correlates with increasing tumor aggressiveness and poor treatment outcomes. Therefore, early diagnosis and effective killing of hypoxic tumor cells are crucial for successful tumor control. There has been a surge of interdisciplinary research aimed at developing functional molecules and nanomaterials that can be used to noninvasively image and efficiently treat hypoxic tumors. These mainly include hypoxia-active nanoparticles, anti-hypoxia agents, and agents that target biomarkers of tumor hypoxia. Hypoxia-active nanoparticles have been intensively investigated and have demonstrated advanced effects on targeting tumor hypoxia. In this review, we present an overview of the reports published to date on hypoxia-activated prodrugs and their nanoparticle forms used in tumor-targeted therapy. Hypoxia-responsive nanoparticles are inactive during blood circulation and normal physiological conditions but are activated by hypoxia once they extravasate into the hypoxic tumor microenvironment. Their use can enhance the efficiency of tumor chemotherapy, radiotherapy, fluorescence and photoacoustic intensity, and other imaging and therapeutic strategies. By targeting the broad habitats of tumors, rather than tumor-specific receptors, this strategy has the potential to overcome the problem of tumor heterogeneity and could be used to design diagnostic and therapeutic nanoparticles for a broad range of solid tumors.
WOS关键词CONJUGATED POLYMER DOTS ; CARBONIC-ANHYDRASE IX ; IN-VIVO ; MITOMYCIN-C ; BIOREDUCTIVE COMPOUND ; ANTICANCER PRODRUGS ; SELECTIVE TOXICITY ; TARGETING HYPOXIA ; CELL CARCINOMA ; DRUG-DELIVERY
资助项目National Key R&D Program of China[2017YFA0700401] ; National Key R&D Program of China[2017YFA0205200] ; National Key R&D Program of China[2018YFC0115500] ; National Natural Science Foundation of China[81227901] ; National Natural Science Foundation of China[81527805] ; National Natural Science Foundation of China[81501540] ; National Natural Science Foundation of China[61231004] ; National Natural Science Foundation of China[81630053]
WOS研究方向Science & Technology - Other Topics ; Pharmacology & Pharmacy
语种英语
出版者DOVE MEDICAL PRESS LTD
WOS记录号WOS:000469112600001
资助机构National Key R&D Program of China ; National Natural Science Foundation of China
源URL[http://ir.ia.ac.cn/handle/173211/24408]  
专题自动化研究所_中国科学院分子影像重点实验室
通讯作者Tian, Jie; Xu, Ke
作者单位1.China Med Univ, Affiliated Hosp 1, Dept Intervent Radiol, 155 Nanjing North St, Shenyang 110000, Liaoning, Peoples R China
2.Chinese Acad Sci, Key Lab Mol Imaging, Inst Automat, Beijing 100190, Peoples R China
3.Beihang Univ, Inst Med Interdisciplinary Innovat, Beijing 100080, Peoples R China
推荐引用方式
GB/T 7714		 Wang, Yaqin,Shang, Wenting,Niu, Meng,et al. Hypoxia-active nanoparticles used in tumor theranostic[J]. INTERNATIONAL JOURNAL OF NANOMEDICINE,2019,14:3705-3722.
APA Wang, Yaqin,Shang, Wenting,Niu, Meng,Tian, Jie,&Xu, Ke.(2019).Hypoxia-active nanoparticles used in tumor theranostic.INTERNATIONAL JOURNAL OF NANOMEDICINE,14,3705-3722.
MLA Wang, Yaqin,et al."Hypoxia-active nanoparticles used in tumor theranostic".INTERNATIONAL JOURNAL OF NANOMEDICINE 14(2019):3705-3722.

入库方式： OAI收割

来源：自动化研究所

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