Transient increased thalamic-sensory connectivity and decreased whole-brain dynamism in autism
文献类型：期刊论文
| 作者 | Fu, Zening1,4; Tu, Yiheng2,3,4; Di, Xin5; Du, Yuhui1,6; Sui, Jing7,8 ; Biswal, Bharat B.5; Zhang, Zhiguo4; de lacy, N.9; Calhoun, V. D.1,10
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| 刊名 | NEUROIMAGE
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| 出版日期 | 2019-04-15 |
| 卷号 | 190页码:191-204 |
| ISSN号 | 1053-8119 |
| DOI | 10.1016/j.neuroimage.2018.06.003 |
| 通讯作者 | Fu, Zening(fzn198637@gmail.com) |
| 英文摘要 | Autism spectrum disorder (ASD) is a neurodevelopmental disorder associated with social communication deficits and restricted/repetitive behaviors and is characterized by large-scale atypical subcortical-cortical connectivity, including impaired resting-state functional connectivity between thalamic and sensory regions. Previous studies have typically focused on the abnormal static connectivity in ASD and overlooked potential valuable dynamic patterns in brain connectivity. However, resting-state brain connectivity is indeed highly dynamic, and abnormalities in dynamic brain connectivity have been widely identified in psychiatric disorders. In this study, we investigated the dynamic functional network connectivity (dFNC) between 51 intrinsic connectivity networks in 170 individuals with ASD and 195 age-matched typically developing (TD) controls using independent component analysis and a sliding window approach. A hard clustering state analysis and a fuzzy meta-state analysis were conducted respectively, for the exploration of local and global aberrant dynamic connectivity patterns in ASD. We examined the group difference in dFNC between thalamic and sensory networks in each functional state and group differences in four high-dimensional dynamic measures. The results showed that compared with TD controls, individuals with ASD show an increase in transient connectivity between hypothalamus/subthalamus and some sensory networks (right postcentral gyrus, bi paracentral lobule, and lingual gyrus) in certain functional states, and diminished global meta-state dynamics of the whole-brain functional network. In addition, these atypical dynamic patterns are significantly associated with autistic symptoms indexed by the Autism Diagnostic Observation Schedule. These converging results support and extend previous observations regarding hyperconnectivity between thalamic and sensory regions and stable whole-brain functional configuration in ASD. Dynamic brain connectivity may serve as a potential biomarker of ASD and further investigation of these dynamic patterns might help to advance our understanding of behavioral differences in this complex neurodevelopmental disorder. |
| WOS关键词 | HIGH-FUNCTIONING INDIVIDUALS ; TIME-VARYING CONNECTIVITY ; RESTING-STATE FMRI ; DEFAULT MODE NETWORK ; SPECTRUM DISORDERS ; SENTENCE COMPREHENSION ; WORKING-MEMORY ; CHILDREN ; CORTEX ; PATTERNS |
| 资助项目 | National Institutes of Health (NIH)[R01EB006841] ; National Institutes of Health (NIH)[R01REB020407] ; National Institutes of Health (NIH)[P20GM103472] ; National Science Foundation (NSF)[1539067] ; National Center for Advancing Translational Sciences of the National Institutes of Health[KL2TR000421] ; National Natural Science Foundation of China[61703253] ; Natural Science Foundation of Shanxi Province[2016021077] |
| WOS研究方向 | Neurosciences & Neurology ; Radiology, Nuclear Medicine & Medical Imaging |
| 语种 | 英语 |
| 出版者 | ACADEMIC PRESS INC ELSEVIER SCIENCE |
| WOS记录号 | WOS:000467540600017 |
| 资助机构 | National Institutes of Health (NIH) ; National Science Foundation (NSF) ; National Center for Advancing Translational Sciences of the National Institutes of Health ; National Natural Science Foundation of China ; Natural Science Foundation of Shanxi Province |
| 源URL | [http://ir.ia.ac.cn/handle/173211/24587]  |
| 专题 | 自动化研究所_脑网络组研究中心 |
| 通讯作者 | Fu, Zening |
| 作者单位 | 1.Mind Res Network, Albuquerque, NM 87106 USA 2.Massachusetts Gen Hosp, Dept Psychiat, Boston, MA 02114 USA 3.Harvard Med Sch, Boston, MA 02115 USA 4.Shenzhen Univ, Sch Biomed Engn, Shenzhen, Peoples R China 5.New Jersey Inst Technol, Dept Biomed Engn, Newark, NJ 07102 USA 6.Shanxi Univ, Sch Comp & Informat Technol, Taiyuan, Shanxi, Peoples R China 7.Chinese Acad Sci, Inst Automat, Brainnetome Ctr, Beijing, Peoples R China 8.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing, Peoples R China 9.Univ Washington, Dept Psychiat & Behav Sci, Seattle, WA 98195 USA 10.Univ New Mexico, Dept Elect & Comp Engn, Albuquerque, NM 87131 USA |
| 推荐引用方式 GB/T 7714 | Fu, Zening,Tu, Yiheng,Di, Xin,et al. Transient increased thalamic-sensory connectivity and decreased whole-brain dynamism in autism[J]. NEUROIMAGE,2019,190:191-204. |
| APA | Fu, Zening.,Tu, Yiheng.,Di, Xin.,Du, Yuhui.,Sui, Jing.,...&Calhoun, V. D..(2019).Transient increased thalamic-sensory connectivity and decreased whole-brain dynamism in autism.NEUROIMAGE,190,191-204. |
| MLA | Fu, Zening,et al."Transient increased thalamic-sensory connectivity and decreased whole-brain dynamism in autism".NEUROIMAGE 190(2019):191-204. |
入库方式： OAI收割
来源：自动化研究所
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