A method for building a genome-connectome bipartite graph model
文献类型:期刊论文
作者 | Yu, Qingbao1; Chen, Jiayu1; Du, Yuhui1,2; Sui, Jing1,3,4,5; Damaraju, Eswar1; Turner, Jessica A.6; van Erp, Theo G. M.7; Macciardi, Fabio7; Belger, Aysenil8; Ford, Judith M.9,10 |
刊名 | JOURNAL OF NEUROSCIENCE METHODS |
出版日期 | 2019-05-15 |
卷号 | 320页码:64-71 |
ISSN号 | 0165-0270 |
关键词 | fMRI FNC SNPs Bipartite graph |
DOI | 10.1016/j.jneumeth.2019.03.011 |
通讯作者 | Chen, Jiayu(jchen@mrn.org) ; Calhoun, Vince D.(vcalhoun@unm.edu) |
英文摘要 | It has been widely shown that genomic factors influence both risk for schizophrenia and variation in functional brain connectivity. Moreover, schizophrenia is characterized by disrupted brain connectivity. In this work, we proposed a genome-connectome bipartite graph model to perform imaging genomic analysis. Functional network connectivity (FNC) was estimated after decomposing resting state functional magnetic resonance imaging data from both healthy controls (HC) and patients with schizophrenia (SZ) into spatial brain components using group independent component analysis (G-ICA). Then 83 FNC connections showing a group difference (HC vs SZ) were selected as fMRI nodes, and eighty-one schizophrenia-related single nucleotide polymorphisms (SNPs) were selected as genetic nodes respectively in the bipartite graph. Edges connecting pairs of genetic and fMRI nodes were defined based on the SNP-FNC associations across subjects evaluated by a general linear model. Results show that some SNP nodes in the bipartite graph have a high degree implying they are influential in modulating brain connectivity and may be more strongly associated with the risk of schizophrenia than other SNPs. A bi-clustering analysis detected a cluster with 15 SNPs interacting with 38 FNC connections, most of which were within or between somato-motor and visual brain areas. This suggests that the activity of these brain regions may be related to common SNPs and provides insights into the pathology of schizophrenia. The findings suggest that the SNP-FNC bipartite graph approach is a novel model to investigate genetic influences on functional brain connectivity in mental illness. |
WOS关键词 | FUNCTIONAL NETWORK CONNECTIVITY ; RESTING-STATE FMRI ; BRAIN NETWORKS ; MULTICENTER FMRI ; HEALTHY CONTROLS ; GENETIC-CONTROL ; SCHIZOPHRENIA ; HERITABILITY ; PARCELLATION ; ACTIVATION |
资助项目 | National Institutes of Health (NIH)[P20GM103472/5P20RR021938] ; National Institutes of Health (NIH)[R01 EB005846] ; National Institutes of Health (NIH)[1R01EB006841] ; National Institutes of Health (NIH)[1R01DA040487] ; National Institutes of Health (NIH)[RO1REB020407] ; National Institutes of Health (NIH)[ROlEB000840] ; National Institutes of Health (NIH)[R37MH43775] ; National Science Foundation (NSF)[1539067] ; National Science Foundation (NSF)[1618551] ; National Science Foundation (NSF)[1631838] ; National Center for Research Resources at the National Institutes of Health[NIH 1 U24 RR021992] ; National Center for Research Resources at the National Institutes of Health[NIH 1 U24 RR025736-01] ; Strategic Priority Research Program of the Chinese Academy of Sciences[XDBS03040100] ; Brain Initiative of Beijing City[Z181100001518005] ; Chinese NSF[81471367] ; Chinese NSF[61773380] ; Chinese NSF[61703253] ; Natural Science Foundation of Shanxi[2016021077] |
WOS研究方向 | Biochemistry & Molecular Biology ; Neurosciences & Neurology |
语种 | 英语 |
出版者 | ELSEVIER SCIENCE BV |
WOS记录号 | WOS:000466260400008 |
资助机构 | National Institutes of Health (NIH) ; National Science Foundation (NSF) ; National Center for Research Resources at the National Institutes of Health ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Brain Initiative of Beijing City ; Chinese NSF ; Natural Science Foundation of Shanxi |
源URL | [http://ir.ia.ac.cn/handle/173211/24591] |
专题 | 自动化研究所_脑网络组研究中心 |
通讯作者 | Chen, Jiayu; Calhoun, Vince D. |
作者单位 | 1.Mind Res Network, 1101 Yale Blvd NE, Albuquerque, NM 87106 USA 2.Shanxi Univ, Sch Comp & Informat Technol, Taiyuan 030006, Shanxi, Peoples R China 3.Chinese Acad Sci, Brainnetome Ctr, Beijing 100190, Peoples R China 4.Chinese Acad Sci, Natl Lab Pattern Recognit, Inst Automat, Beijing 100190, Peoples R China 5.Univ Chinese Acad Sci Beijing, CAS Ctr Excellence Brain Sci & Intelligence Techn, Beijing 100049, Peoples R China 6.Georgia State Univ, Dept Psychol, Univ Plaza, Atlanta, GA 30303 USA 7.Univ Calif Irvine, Dept Psychiat & Human Behav, Sch Med, Irvine, CA 92697 USA 8.Univ N Carolina, Dept Psychiat, Chapel Hill, NC 27514 USA 9.Univ Calif San Francisco, Dept Psychiat, San Francisco, CA 94143 USA 10.San Francisco VA Med Ctr, San Francisco, CA 94121 USA |
推荐引用方式 GB/T 7714 | Yu, Qingbao,Chen, Jiayu,Du, Yuhui,et al. A method for building a genome-connectome bipartite graph model[J]. JOURNAL OF NEUROSCIENCE METHODS,2019,320:64-71. |
APA | Yu, Qingbao.,Chen, Jiayu.,Du, Yuhui.,Sui, Jing.,Damaraju, Eswar.,...&Calhoun, Vince D..(2019).A method for building a genome-connectome bipartite graph model.JOURNAL OF NEUROSCIENCE METHODS,320,64-71. |
MLA | Yu, Qingbao,et al."A method for building a genome-connectome bipartite graph model".JOURNAL OF NEUROSCIENCE METHODS 320(2019):64-71. |
入库方式: OAI收割
来源:自动化研究所
浏览0
下载0
收藏0
其他版本
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。