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Endoscopic Cerenkov luminescence imaging and image-guided tumor resection on hepatocellular carcinoma-bearing mouse models

文献类型：期刊论文

作者Zhang, Zeyu1,2; Cai, Meishan2,3; Bao, Chengpeng2; Hu, Zhenhua2,3; Tian, Jie1,2,3
刊名NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
出版日期2019-04-01
卷号17页码:62-70
ISSN号1549-9634
关键词Cerenkov luminescence imaging Endoscopy Image-guided surgery Hepaiocellular carcinoma (HCC)
DOI10.1016/j.nano.2018.12.017
通讯作者Hu, Zhenhua(zhenhua.hu@ia.ac.cn) ; Tian, Jie(tian@ieee.org)
英文摘要Detecting deep tumors inside living subject is still challenging for Cerenkov luminescence imaging (CLI). In this study, a high-sensitivity endoscopic CLI (ECLI) system was developed with a dual-mode deep cooling approach to improve the imaging sensitivity. System was characterized through a series of ex vivo studies. Furthermore, subcutaneous and orthotropic human hepatocellular carcinoma (MCC) mouse models were established for ECLI guided tumor resection in vivo. The results showed that the ECLI system had spatial resolution (62.5 mu m) and imaging sensitivity (6.29 x 10 (-2 )kBq/mu l( )(18)F-FDG). The in vivo experimental data from the HCC mouse models demonstrated that the system was effective to intraoperatively guide the surgery of deep tumors such as liver cancer. Overall, the developed system exhibits promising potential for the applications of tumor precise resection and novel nanoprobe based optical imaging. (C) 2019 Elsevier Inc. All rights reserved.
WOS关键词LIVER RESECTION ; TOMOGRAPHY ; SYSTEM ; CLI
资助项目National Key Research and Development Program of China[2016YFC0102600] ; National Key Research and Development Program of China[2017YFA0205200] ; National Natural Science Foundation of China (NSFC)[81227901] ; National Natural Science Foundation of China (NSFC)[81527805] ; National Natural Science Foundation of China (NSFC)[61622117] ; National Natural Science Foundation of China (NSFC)[81671759] ; Beijing Nova Program[Z181100006218046] ; Scientific Instrument Developing Project of the Chinese Academy of Sciences[YZ201672] ; Chinese Academy of Sciences[GJJSTD20170004]
WOS研究方向Science & Technology - Other Topics ; Research & Experimental Medicine
语种英语
出版者ELSEVIER SCIENCE BV
WOS记录号WOS:000467581100006
资助机构National Key Research and Development Program of China ; National Natural Science Foundation of China (NSFC) ; Beijing Nova Program ; Scientific Instrument Developing Project of the Chinese Academy of Sciences ; Chinese Academy of Sciences
源URL[http://ir.ia.ac.cn/handle/173211/24599]  
专题自动化研究所_中国科学院分子影像重点实验室
通讯作者Hu, Zhenhua; Tian, Jie
作者单位1.Xidian Univ, Sch Life Sci & Technol, Xian 710071, Shaanxi, Peoples R China
2.Chinese Acad Sci, Inst Automat, State Key Lab Management & Control Complex Syst, Key Lab Mol Imaging,Beijing Key Lab Mol Imaging, Beijing 100190, Peoples R China
3.Univ Chinese Acad Sci, Beijing, Peoples R China
推荐引用方式
GB/T 7714		 Zhang, Zeyu,Cai, Meishan,Bao, Chengpeng,et al. Endoscopic Cerenkov luminescence imaging and image-guided tumor resection on hepatocellular carcinoma-bearing mouse models[J]. NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE,2019,17:62-70.
APA Zhang, Zeyu,Cai, Meishan,Bao, Chengpeng,Hu, Zhenhua,&Tian, Jie.(2019).Endoscopic Cerenkov luminescence imaging and image-guided tumor resection on hepatocellular carcinoma-bearing mouse models.NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE,17,62-70.
MLA Zhang, Zeyu,et al."Endoscopic Cerenkov luminescence imaging and image-guided tumor resection on hepatocellular carcinoma-bearing mouse models".NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE 17(2019):62-70.

入库方式： OAI收割

来源：自动化研究所

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