A novel mouse model of orthotopic extrahepatic cholangiocarcinoma confirmed with molecular imaging
文献类型：期刊论文
| 作者 | Song, Xiaodong1,2; Shao, Zili1; Han, Menglin1; Liang, Huihong1 |
| 刊名 | TRANSLATIONAL CANCER RESEARCH
 |
| 出版日期 | 2019-04-01 |
| 卷号 | 8期号:2页码:583-591 |
| 关键词 | Extrahepatic cholangiocarcinoma (extrahepatic CCA) xenograft orthotopic mice model molecular imaging |
| ISSN号 | 2218-676X |
| DOI | 10.21037/tcr.2019.03.19 |
| 通讯作者 | Liang, Huihong(beanth@163.com) |
| 英文摘要 | Background: Cholangiocarcinoma (CCA) is the second most common primary hepatic malignancy in humans. Although early-stage CCA can be managed with surgery, CCA is considered incurable at advanced stages and results in poor quality of life and overall survival. A good orthotopic CCA animal model is essential to perform basic studies investigating CCA in order to understand the molecular pathways that underlie cancer development, and to develop new therapies for the prevention and treatment of CCA. However, to the best of our knowledge, orthotopic extrahepatic CCA animal models have not yet been reported in the literature. Methods: In this study, we established an orthotopic extrahepatic CCA model in mice using a two-step surgical procedure. Results: The characteristics of this model were confirmed using molecular imaging and histological analysis. Conclusions: We believe that this CCA. animal model, which can be established quickly, easily, and with good reproducibility, will help guide research on novel diagnostic and treatment strategies for extrahepatic CCA. |
| WOS关键词 | HILAR CHOLANGIOCARCINOMA ; TARGETED DELIVERY ; TUMOR-GROWTH ; CELLS ; SENSITIVITY ; MANAGEMENT |
| 资助项目 | Guangzhou medical science and technology project[20171A010304] |
| WOS研究方向 | Oncology |
| 语种 | 英语 |
| WOS记录号 | WOS:000466506700028 |
| 出版者 | AME PUBL CO |
| 资助机构 | Guangzhou medical science and technology project |
| 源URL | [http://ir.ia.ac.cn/handle/173211/24910]  |
| 专题 | 自动化研究所_中国科学院分子影像重点实验室 |
| 通讯作者 | Liang, Huihong |
| 作者单位 | 1.Guangzhou Med Univ, Affiliated Hosp 2, Dept Hepatobiliary Surg, 250 Changgang Rd, Guangzhou 510260, Guangdong, Peoples R China 2.Chinese Acad Sci, Inst Automat, Key Lab Mol Imaging, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | Song, Xiaodong,Shao, Zili,Han, Menglin,et al. A novel mouse model of orthotopic extrahepatic cholangiocarcinoma confirmed with molecular imaging[J]. TRANSLATIONAL CANCER RESEARCH,2019,8(2):583-591. |
| APA | Song, Xiaodong,Shao, Zili,Han, Menglin,&Liang, Huihong.(2019).A novel mouse model of orthotopic extrahepatic cholangiocarcinoma confirmed with molecular imaging.TRANSLATIONAL CANCER RESEARCH,8(2),583-591. |
| MLA | Song, Xiaodong,et al."A novel mouse model of orthotopic extrahepatic cholangiocarcinoma confirmed with molecular imaging".TRANSLATIONAL CANCER RESEARCH 8.2(2019):583-591. |
入库方式： OAI收割
来源：自动化研究所
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