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Development and validation of an individualized nomogram to identify occult peritoneal metastasis in patients with advanced gastric cancer

文献类型：期刊论文

作者Dong, D.1,2,3; Tang, L.2; Li, Z. -Y4; Fang, M-J1,3; Gao, J-B5; Shan, X-H6; Ying, X-J4; Sun, Y-S2; Fu, J.2; Wang, X-X6
刊名ANNALS OF ONCOLOGY
出版日期2019-03-01
卷号30期号:3页码:431-438
ISSN号0923-7534
关键词occult peritoneal metastasis radiomic nomogram advanced gastric cancer
DOI10.1093/annonc/mdz001
通讯作者Tian, J.(jie.tian@ia.ac.cn) ; Ji, J-F(jijiafu@hsc.pku.edu.cn)
英文摘要Background Occult peritoneal metastasis (PM) in advanced gastric cancer (AGC) patients is highly possible to be missed on computed tomography (CT) images. Patients with occult PMs are subject to late detection or even improper surgical treatment. We therefore aimed to develop a radiomic nomogram to preoperatively identify occult PMs in AGC patients. Patients and methods A total of 554 AGC patients from 4 centers were divided into 1 training, 1 internal validation, and 2 external validation cohorts. All patients' PM status was firstly diagnosed as negative by CT, but later confirmed by laparoscopy (PM-positive n=122, PM-negative n=432). Radiomic signatures reflecting phenotypes of the primary tumor (RS1) and peritoneum region (RS2) were built as predictors of PM from 266 quantitative image features. Individualized nomograms of PM status incorporating RS1, RS2, or clinical factors were developed and evaluated regarding prediction ability. Results RS1, RS2, and Lauren type were significant predictors of occult PM (all P<0.05). A nomogram of these three factors demonstrated better diagnostic accuracy than the model with RS1, RS2, or clinical factors alone (all net reclassification improvement P<0.05). The area under curve yielded was 0.958 [95% confidence interval (CI) 0.923-0.993], 0.941 (95% CI 0.904-0.977), 0.928 (95% CI 0.886-0.971), and 0.920 (95% CI 0.862-0.978) for the training, internal, and two external validation cohorts, respectively. Stratification analysis showed that this nomogram had potential generalization ability. Conclusion CT phenotypes of both primary tumor and nearby peritoneum are significantly associated with occult PM status. A nomogram of these CT phenotypes and Lauren type has an excellent prediction ability of occult PM, and may have significant clinical implications on early detection of occult PM for AGC.
WOS关键词BORRMANN TYPE ; RADIOMICS ; CHEMOTHERAPY ; CT
资助项目National Key R&D Program of China[2017YFA0205200] ; National Key R&D Program of China[2017YFC1308700] ; National Key R&D Program of China[2017YFC1309100] ; National Key R&D Program of China[2016YFC0103803] ; National Key R&D Program of China[2017YFA0700401] ; National Natural Science Foundation of China[81771924] ; National Natural Science Foundation of China[81501616] ; National Natural Science Foundation of China[81227901] ; National Natural Science Foundation of China[81671851] ; National Natural Science Foundation of China[81527805] ; National Natural Science Foundation of China[61671449] ; National Natural Science Foundation of China[61622117] ; Beijing Natural Science Foundation[L182061] ; Beijing Natural Science Foundation[Z180001] ; Beijing Municipal Science and Technology Commission[Z171100000117023] ; Beijing Municipal Science and Technology Commission[Z161100002616022] ; Instrument Developing Project of the Chinese Academy of Sciences[YZ201502] ; Youth Innovation Promotion Association CAS[2017175]
WOS研究方向Oncology
语种英语
出版者OXFORD UNIV PRESS
WOS记录号WOS:000465084000017
资助机构National Key R&D Program of China ; National Natural Science Foundation of China ; Beijing Natural Science Foundation ; Beijing Municipal Science and Technology Commission ; Instrument Developing Project of the Chinese Academy of Sciences ; Youth Innovation Promotion Association CAS
源URL[http://ir.ia.ac.cn/handle/173211/24932]  
专题自动化研究所_中国科学院分子影像重点实验室
通讯作者Tian, J.; Ji, J-F; Tian, Jie
作者单位1.Chinese Acad Sci, Inst Automat, CAS Key Lab Mol Imaging, 95 Zhongguancun East Rd, Beijing 100190, Peoples R China
2.Peking Univ, Key Lab Carcinogenesis & Translat Res, Canc Hosp & Inst, Minist Educ,Radiol Dept, Beijing, Peoples R China
3.Univ Chinese Acad Sci, Beijing, Peoples R China
4.Peking Univ, Key Lab Carcinogenesis & Translat Res, Gastrointestinal Canc Ctr, Minist Educ,Canc Hosp & Inst, 52 Fu Cheng Rd, Beijing 100142, Peoples R China
5.Zhengzhou Univ, Dept Radiol, Affiliated Hosp 1, Zhengzhou, Henan, Peoples R China
6.Jiangsu Univ, Dept Radiol, Affiliated Peoples Hosp, Zhenjiang, Jiangsu, Peoples R China
7.Kunming Med Univ, Yunnan Canc Hosp, Dept Radiol, Affiliated Hosp 3, Kunming, Yunnan, Peoples R China
8.Beihang Univ, Beijing Adv Innovat Ctr Big Data Based Precis Med, Sch Med, Beijing, Peoples R China
推荐引用方式
GB/T 7714		 Dong, D.,Tang, L.,Li, Z. -Y,et al. Development and validation of an individualized nomogram to identify occult peritoneal metastasis in patients with advanced gastric cancer[J]. ANNALS OF ONCOLOGY,2019,30(3):431-438.
APA Dong, D..,Tang, L..,Li, Z. -Y.,Fang, M-J.,Gao, J-B.,...&Fang, Mengjie.(2019).Development and validation of an individualized nomogram to identify occult peritoneal metastasis in patients with advanced gastric cancer.ANNALS OF ONCOLOGY,30(3),431-438.
MLA Dong, D.,et al."Development and validation of an individualized nomogram to identify occult peritoneal metastasis in patients with advanced gastric cancer".ANNALS OF ONCOLOGY 30.3(2019):431-438.

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来源：自动化研究所

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