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Genetic contribution of catechol-O-methyltransferase in dorsolateral prefrontal cortex functional changes in the first episode schizophrenia

文献类型：期刊论文

作者Kang, Yafei1; Huang, Kexin1; Lv, Yahui1; Zhang, Wei1; Cai, Suping1; Wang, Yubo1; Wang, Qiang2; Huang, Liyu1; Wang, Jijun3; Tian, Jie1,4,5
刊名BEHAVIOURAL BRAIN RESEARCH
出版日期2019-05-17
卷号364页码:225-232
关键词First episode schizophrenia Catechol-O-methyltransferase Dorsolateral prefrontal cortex Resting state functional connectivity Negative symptoms
ISSN号0166-4328
DOI10.1016/j.bbr.2019.02.012
通讯作者Huang, Liyu(huangly@mail.xidian.edu.cn) ; Wang, Jijun(jijunwang27@163.com) ; Tian, Jie(tian@ieee.org)
英文摘要Catechol-O-methyltransferase (COMT) gene variants have been reported to be implicated in the pathogenesis of psychotic symptoms in schizophrenia, especially in negative symptoms. These symptoms including apathy, blunted affect, social withdrawal and motor retardation. Neuroimaging studies suggested that negative symptoms appear to be associated with impaired activities of the prefrontal cortex in particular the dorsolateral prefrontal cortex (DLPFC). Given that the COMT gene is highly expressed in the DLPFC, it is poorly understood whether the disease state and COMT val(158)met polymorphisms have main and interactive effect on the resting state functional connectivity (RSFC) of DLPFC-related pathways. To this end, fifty-five first episode schizophrenia (FES) and fifty-three healthy controls were genotyped using blood samples and underwent magnetic resonance imaging scanning. Seed-based voxel wise functional connectivity analysis was performed by placing bilateral pairs of seeds with DLPFC in area 46 defined by Brodmann's atlas. A two-ways ANCOVA model was performed with val(158)met genotypes and disease state as the between subjects factors. Significant disease x COMT interactive effect was found mainly in the left DLPFC with the left anterior cingulate cortex, right precuneus, right superior parietal gyrus, which were overlapped with disease main effect. And these RSFC had positive correlations with affective blunting scores in FES patients with val homozygotes, but not with met carriers. Our results showed that the disease and the genotypes in COMT gene have significant interactive effect on RSFC of DLPFC and provided evidence for a disease-dependent patterm of gene action.
WOS关键词ANTERIOR CINGULATE CORTEX ; NEGATIVE SYMPTOMS ; COMT VAL158MET ; WORKING-MEMORY ; CONNECTIVITY ; ASSOCIATION ; DYSFUNCTION ; MODULATION ; GENOTYPE ; REWARD
资助项目National Natural Science Foundation of China[81671778] ; National Natural Science Foundation of China[81671332] ; National Natural Science Foundation of China[81701787] ; National Natural Science Foundation of China[81801789] ; China Postdoctoral Science Foundation[2017M623128] ; Fundamental Research Funds for the Central Universities[JB181209]
WOS研究方向Behavioral Sciences ; Neurosciences & Neurology
语种英语
WOS记录号WOS:000463130800025
出版者ELSEVIER SCIENCE BV
资助机构National Natural Science Foundation of China ; China Postdoctoral Science Foundation ; Fundamental Research Funds for the Central Universities
源URL[http://ir.ia.ac.cn/handle/173211/24938]  
专题自动化研究所_中国科学院分子影像重点实验室
通讯作者Huang, Liyu; Wang, Jijun; Tian, Jie
作者单位1.Xidian Univ, Sch Life Sci & Technol, Xian, Shaanxi, Peoples R China
2.Xi An Jiao Tong Univ, Affiliated Hosp 1, Dept Anesthesiol, Xian, Shaanxi, Peoples R China
3.Shanghai Jiao Tong Univ, Shanghai Mental Hlth Ctr, Shanghai Key Lab Psychot Disorders, Sch Med, Shanghai, Peoples R China
4.Minist Educ, Engn Res Ctr Mol & Neuro Imaging, Xian, Shaanxi, Peoples R China
5.Chinese Acad Sci, Inst Automat, Beijing, Peoples R China
推荐引用方式
GB/T 7714		 Kang, Yafei,Huang, Kexin,Lv, Yahui,et al. Genetic contribution of catechol-O-methyltransferase in dorsolateral prefrontal cortex functional changes in the first episode schizophrenia[J]. BEHAVIOURAL BRAIN RESEARCH,2019,364:225-232.
APA Kang, Yafei.,Huang, Kexin.,Lv, Yahui.,Zhang, Wei.,Cai, Suping.,...&Tian, Jie.(2019).Genetic contribution of catechol-O-methyltransferase in dorsolateral prefrontal cortex functional changes in the first episode schizophrenia.BEHAVIOURAL BRAIN RESEARCH,364,225-232.
MLA Kang, Yafei,et al."Genetic contribution of catechol-O-methyltransferase in dorsolateral prefrontal cortex functional changes in the first episode schizophrenia".BEHAVIOURAL BRAIN RESEARCH 364(2019):225-232.

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来源：自动化研究所

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