Association of Per3 length polymorphism with susceptibility of Alzheimer disease (AD) in Chinese population
文献类型：期刊论文
| 作者 | Xiang, Hu1; Huang, Changquan1; Guo, Qiong1; Liu, QingXiu1; Xiong, Gang2
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| 刊名 | BIOLOGICAL RHYTHM RESEARCH
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| 出版日期 | 2019-05-04 |
| 卷号 | 50期号:3页码:447-453 |
| 关键词 | Circadian rhythms clock genes Per3 polymorphism Alzheimer disease |
| ISSN号 | 0929-1016 |
| DOI | 10.1080/09291016.2018.1464627 |
| 通讯作者 | Huang, Changquan(19030990101@163.com) |
| 英文摘要 | Objectives: The association of Per3 length polymorphism with susceptibility of Alzheimer Disease (AD) was examined in the present study. Methods: This study was constructed using the case-control method and investigated the association of Per3 length polymorphism with susceptibility of AD. Genotypes of APOE and Per3 length were determined by a PCR restriction fragment length polymorphism detection method. Results: In this study, we gathered 130 unrelated AD patients and 188 controls in performing an analysis the association of Per3 length polymorphism with susceptibility of AD. In the whole sample or APOE epsilon 4 non-carriers, an increased prevalence of five repeat homozygotes of Per3 length in AD patients had significant higher than that in controls (in the whole sample: chi(2) = 7.261,= 0.0176; in APOE epsilon 4 non-carriers: chi(2) = 6.086, p = 0.030). And, among APOE epsilon 4 carriers, an increased prevalence of five repeat homozygotes of Per3 length in AD patients had also significant higher than that in controls (chi(2) = 3.893, p = 0.0319). Conclusions: Among APOE epsilon 4 non-carriers, five repeat homozygotes of Per3 length was associated with a high susceptibility of AD among APOE epsilon 4 carriers and non-carriers. |
| WOS关键词 | GREATER-THAN-T ; RISK ; GENOTYPE |
| 资助项目 | National Natural Science Foundation of China[61773381] ; National Natural Science Foundation of China[61773382] ; Science and Technology Graveness Project of Sichuan Province[2010FZ0061] ; Illustrious Youth Specialist Project of Sichuan Province[2012 JQ0050] ; Sichuan provincial health and Family Planning Commission[17ZD014] |
| WOS研究方向 | Life Sciences & Biomedicine - Other Topics ; Physiology |
| 语种 | 英语 |
| WOS记录号 | WOS:000462837500012 |
| 出版者 | TAYLOR & FRANCIS LTD |
| 资助机构 | National Natural Science Foundation of China ; Science and Technology Graveness Project of Sichuan Province ; Illustrious Youth Specialist Project of Sichuan Province ; Sichuan provincial health and Family Planning Commission |
| 源URL | [http://ir.ia.ac.cn/handle/173211/24940]  |
| 专题 | 自动化研究所_复杂系统管理与控制国家重点实验室_先进控制与自动化团队 |
| 通讯作者 | Huang, Changquan |
| 作者单位 | 1.Third Hosp Mianyang, Dept Geriatr, Mianyang, Peoples R China 2.Chinese Acad Sci, Inst Automat, State Key Lab Management & Control Complex Syst, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xiang, Hu,Huang, Changquan,Guo, Qiong,et al. Association of Per3 length polymorphism with susceptibility of Alzheimer disease (AD) in Chinese population[J]. BIOLOGICAL RHYTHM RESEARCH,2019,50(3):447-453. |
| APA | Xiang, Hu,Huang, Changquan,Guo, Qiong,Liu, QingXiu,&Xiong, Gang.(2019).Association of Per3 length polymorphism with susceptibility of Alzheimer disease (AD) in Chinese population.BIOLOGICAL RHYTHM RESEARCH,50(3),447-453. |
| MLA | Xiang, Hu,et al."Association of Per3 length polymorphism with susceptibility of Alzheimer disease (AD) in Chinese population".BIOLOGICAL RHYTHM RESEARCH 50.3(2019):447-453. |
入库方式： OAI收割
来源：自动化研究所
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