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Differentiation of primary central nervous system lymphoma from high-grade glioma and brain metastasis using arterial spin labeling and dynamic contrast-enhanced magnetic resonance imaging

文献类型：期刊论文

作者Xi, Yi-bin1; Kang, Xiao-wei1; Wang, Ning1; Liu, Ting-ting1; Zhu, Yuan-qiang1; Cheng, Guang2; Wang, Kai2; Li, Chen1; Guo, Fan1,3; Yin, Hong1
刊名EUROPEAN JOURNAL OF RADIOLOGY
出版日期2019-03-01
卷号112页码:59-64
关键词Primary central nervous system lymphoma High-grade glioma Metastasis Arterial spin labeling Dynamic contrast-enhanced perfusion
ISSN号0720-048X
DOI10.1016/j.ejrad.2019.01.008
通讯作者Guo, Fan(guofan@fmmu.edu.cn) ; Yin, Hong(yinhong@fmmu.edu.cn)
英文摘要Background and purpose: Conventional magnetic resonance imaging (MRI) is sometimes difficult to distinguish primary central nervous system lymphoma (PCNSL) from other malignant brain tumors effectively. The study aimed to evaluate the diagnostic performance of arterial spin labeling (ASL) and dynamic contrast-enhanced (DCE)-derived permeability parameters to differentiate PCNSL from high-grade glioma (HGG) and brain metastasis. Materials and methods: Eight patients with PCNSL, twenty one patients with HGG and six brain metastasis underwent preoperative 3.0-T MR imaging including conventional, ASL and DCE. Quantitative parameters including relative cerebral blood flow (rCBF), extravascular extracellular volume fraction (V-e) and the volume transfer constant (K-trans) among PCNSL, HGG and metastasis were compared with a one-way analysis of variance. In addition, the area under the receiver-operating characteristic (ROC) curve (AUC) was constructed to evaluate the differentiation diagnostic performance of each parameter and the combination. Results: The PCNSL demonstrated significantly lower rCBF, higher K-trans and V-e compared with HGG and metastasis. For the ROC analyses, both K-trans and rCBF had good diagnostic performance for discriminating PCNSL from HGG and metastasis, with the AUC of 0.880 and 0.889. With the combination of rCBF and K-trans the diagnostic ability for PCNSL was improved with AUC of 0.986. Conclusion: rCBF and K-trans are useful parameters for differentiating PCNSL from HGG and brain metastasis. The combination of rCBF and K-trans further helps to improve the diagnostic performance of PCNSL.
WOS关键词PRIMARY CNS LYMPHOMA ; GLIOBLASTOMA-MULTIFORME ; PERFUSION MRI ; DIFFUSION ; PERMEABILITY ; VOLUME ; TUMORS
资助项目National Natural Science Foundation of China[81400952] ; National Natural Science Foundation of China[81372457]
WOS研究方向Radiology, Nuclear Medicine & Medical Imaging
语种英语
WOS记录号WOS:000458752500009
出版者ELSEVIER IRELAND LTD
资助机构National Natural Science Foundation of China
源URL[http://ir.ia.ac.cn/handle/173211/25030]  
专题自动化研究所_中国科学院分子影像重点实验室
通讯作者Guo, Fan; Yin, Hong
作者单位1.Fourth Mil Med Univ, Xijing Hosp, Dept Radiol, Xian 710032, Shaanxi, Peoples R China
2.Fourth Mil Med Univ, Xijing Hosp, Xijing Inst Clin Neurosci, Dept Neurosurg, Xian 710032, Shaanxi, Peoples R China
3.Chinese Acad Sci, Key Lab Mol Imaging, Inst Automat, Beijing 100190, Peoples R China
推荐引用方式
GB/T 7714		 Xi, Yi-bin,Kang, Xiao-wei,Wang, Ning,et al. Differentiation of primary central nervous system lymphoma from high-grade glioma and brain metastasis using arterial spin labeling and dynamic contrast-enhanced magnetic resonance imaging[J]. EUROPEAN JOURNAL OF RADIOLOGY,2019,112:59-64.
APA Xi, Yi-bin.,Kang, Xiao-wei.,Wang, Ning.,Liu, Ting-ting.,Zhu, Yuan-qiang.,...&Yin, Hong.(2019).Differentiation of primary central nervous system lymphoma from high-grade glioma and brain metastasis using arterial spin labeling and dynamic contrast-enhanced magnetic resonance imaging.EUROPEAN JOURNAL OF RADIOLOGY,112,59-64.
MLA Xi, Yi-bin,et al."Differentiation of primary central nervous system lymphoma from high-grade glioma and brain metastasis using arterial spin labeling and dynamic contrast-enhanced magnetic resonance imaging".EUROPEAN JOURNAL OF RADIOLOGY 112(2019):59-64.

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来源：自动化研究所

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