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IDH mutation-specific radiomic signature in lower-grade gliomas

文献类型：期刊论文

作者Liu, Xing1; Li, Yiming1; Li, Shaowu2; Fan, Xing1; Sun, Zhiyan1; Yang, Zhengyi4; Wang, Kai5; Zhang, Zhong3; Jiang, Tao1,3,6,7,8,9; Liu, Yong4,10
刊名AGING-US
出版日期2019-01-31
卷号11期号:2页码:673-696
ISSN号1945-4589
关键词isocitrate dehydrogenase lower grade gliomas radiomic signature transcriptome-radiomic analysis prognostic signature
DOI10.18632/aging.101769
通讯作者Wang, Yinyan(tiantanyinyan@126.com)
英文摘要Unravelling the heterogeneity is the central challenge for glioma precession oncology. In this study, we extracted quantitative image features from T2-weighted MR images and revealed that the isocitrate dehydrogenase (IDH) wild type and mutant lower grade gliomas (LGGs) differed in their expression of 146 radiomic descriptors. The logistic regression model algorithm further reduced these to 86 features. The classification model could discriminate the two types in both the training and validation sets with area under the curve values of 1.0000 and 0.9932, respectively. The transcriptome-radiomic analysis revealed that these features were associated with the immune response, biological adhesion, and several malignant behaviors, all of which are consistent with biological processes that are differentially expressed in IDH wild type and IDH mutant LGGs. Finally, a prognostic signature showed an ability to stratify IDH mutant LGGs into high and low risk groups with distinctive outcomes. By extracting a large number of radiomic features, we identified an IDH mutation-specific radiomic signature with prognostic implications. This radiomic signature may provide a way to non-invasively discriminate lower-grade gliomas as with or without the IDH mutation.
WOS关键词ANAPLASTIC GLIOMAS ; TEXTURE ANALYSIS ; CLASSIFICATION ; SURVIVAL ; FEATURES ; CANCER ; ATRX ; 2-HYDROXYGLUTARATE ; HETEROGENEITY ; METABOLISM
资助项目Beijing Natural Science Foundation[7174295] ; National Natural Science Foundation of China[81601452] ; Beijing Postdoctoral Research Foundation[2016ZZ-37] ; National Basic Research Program of China[2015CB755500] ; National Key Research and Development Plan[2016YFC0902500]
WOS研究方向Cell Biology ; Geriatrics & Gerontology
语种英语
出版者IMPACT JOURNALS LLC
WOS记录号WOS:000459384600030
资助机构Beijing Natural Science Foundation ; National Natural Science Foundation of China ; Beijing Postdoctoral Research Foundation ; National Basic Research Program of China ; National Key Research and Development Plan
源URL[http://ir.ia.ac.cn/handle/173211/25036]  
专题自动化研究所_脑网络组研究中心
通讯作者Wang, Yinyan
作者单位1.Capital Med Univ, Beijing Neurosurg Inst, Beijing, Peoples R China
2.Capital Med Univ, Beijing Neurosurg Inst, Neurol Imaging Ctr, Beijing, Peoples R China
3.Capital Med Univ, Beijing Tiantan Hosp, Dept Neurosurg, Beijing, Peoples R China
4.Chinese Acad Sci, Inst Automat, Brainnetome Ctr, Beijing, Peoples R China
5.Capital Med Univ, Beijing Tiantan Hosp, Dept Nucl Med, Beijing, Peoples R China
6.Beijing Inst Brain Disorders, Ctr Brain Tumor, Beijing, Peoples R China
7.China Natl Clin Res Ctr Neurol Dis, Beijing, Peoples R China
8.Chinese Glioma Genome Atlas Network CGGA, Beijing, Peoples R China
9.Asian Glioma Genome Atlas Network AGGA, Beijing, Peoples R China
10.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing, Peoples R China
推荐引用方式
GB/T 7714		 Liu, Xing,Li, Yiming,Li, Shaowu,et al. IDH mutation-specific radiomic signature in lower-grade gliomas[J]. AGING-US,2019,11(2):673-696.
APA Liu, Xing.,Li, Yiming.,Li, Shaowu.,Fan, Xing.,Sun, Zhiyan.,...&Wang, Yinyan.(2019).IDH mutation-specific radiomic signature in lower-grade gliomas.AGING-US,11(2),673-696.
MLA Liu, Xing,et al."IDH mutation-specific radiomic signature in lower-grade gliomas".AGING-US 11.2(2019):673-696.

入库方式： OAI收割

来源：自动化研究所

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