The Shared and Distinct White Matter Networks Between Drug-Naive Patients With Obsessive-Compulsive Disorder and Schizophrenia
文献类型：期刊论文
| 作者 | Qin, Jiaolong1,2,3 ; Sui, Jing2,3,4; Ni, Huangjing5; Wang, Shuai6,7; Zhang, Fuquan6,7; Zhou, Zhenhe6,7; Tian, Lin6,7
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| 刊名 | FRONTIERS IN NEUROSCIENCE
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| 出版日期 | 2019-02-21 |
| 卷号 | 13页码:10 |
| 关键词 | obsessive-compulsive disorder schizophrenia diffusion MRI graphical measures putamen network topology |
| ISSN号 | 1662-453X |
| DOI | 10.3389/fnins.2019.00096 |
| 通讯作者 | Tian, Lin(tianz@njmu.edu.cn) |
| 英文摘要 | Background: Obsessive-compulsive disorder (OCD) and schizophrenia (SZ) as two severe mental disorders share many clinical symptoms, and have a tight association on the psychopathological level. However, the neurobiological substrates between these two diseases remain unclear. To the best of our knowledge, no study has directly compared OCD with SZ from the perspective of white matter (WM) networks. Methods: Graph theory and network-based statistic methods were applied to diffusion MRI to investigate and compare the WM topological characteristics among 29 drug-naive OCDs, 29 drug-naive SZs, and 65 demographically-matched healthy controls (NC). Results: Compared to NCs, OCDs showed the alterations of nodal efficiency and strength in orbitofrontal (OFG) and middle frontal gyrus (MFG), while SZs exhibited widely-distributed abnormalities involving the OFG, MFG, fusiform gyrus, heschl gyrus, calcarine, lingual gyrus, putamen, and thalamus, and most of these regions also showed a significant difference from OCDs. Moreover, SZs had significantly fewer connections in striatum and visual/auditory cortices than OCDs. The right putamen consistently showed significant differences between both disorders on nodal characteristics and structural connectivity. Conclusions: SZ and OCD present different level of anatomical impairment and some distinct topological patterns, and the former has more serious and more widespread disruptions. The significant differences between both disorders are observed in many regions involving the frontal, temporal, occipital, and subcortical regions. Particularly, putamen may serve as a potential imaging marker to distinguish these two disorders and may be the key difference in their pathological changes. |
| WOS关键词 | ABNORMAL TOPOLOGICAL ORGANIZATION ; STRUCTURAL BRAIN NETWORKS ; AGE-OF-ONSET ; CONNECTIVITY ; MRI ; RELIABILITY ; ATTENTION ; SUBTYPES ; ANATOMY ; DORSAL |
| 资助项目 | China Natural Science Foundation[61773380] ; China Natural Science Foundation[81871081] ; China Natural Science Foundation[81701346] ; Strategic Priority Research Program of the Chinese Academy of Sciences[XDB03040100] ; Special Foundation for Jiangsu Young Medical Talents[QNRC2016175] |
| WOS研究方向 | Neurosciences & Neurology |
| 语种 | 英语 |
| WOS记录号 | WOS:000459256200001 |
| 出版者 | FRONTIERS MEDIA SA |
| 资助机构 | China Natural Science Foundation ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Special Foundation for Jiangsu Young Medical Talents |
| 源URL | [http://ir.ia.ac.cn/handle/173211/25050]  |
| 专题 | 自动化研究所_脑网络组研究中心 |
| 通讯作者 | Tian, Lin |
| 作者单位 | 1.Nanjing Univ Sci & Technol, Minist Educ, Key Lab Intelligent Percept & Syst High Dimens In, Sch Comp Sci & Engn, Nanjing, Jiangsu, Peoples R China 2.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing, Peoples R China 3.Chinese Acad Sci, Brainnetome Ctr, Inst Automat, Beijing, Peoples R China 4.Chinese Acad Sci, Inst Automat, Ctr Excellence Brain Sci, Beijing, Peoples R China 5.Nanjing Univ Posts & Telecommun, Smart Hlth Big Data Anal & Locat Serv Engn Lab Ji, Nanjing, Jiangsu, Peoples R China 6.Nanjing Med Univ, Affiliated Wuxi Mental Hlth Ctr, Wuxi, Peoples R China 7.Wuxi Tongren Int Rehabil Hosp, Wuxi, Peoples R China |
| 推荐引用方式 GB/T 7714 | Qin, Jiaolong,Sui, Jing,Ni, Huangjing,et al. The Shared and Distinct White Matter Networks Between Drug-Naive Patients With Obsessive-Compulsive Disorder and Schizophrenia[J]. FRONTIERS IN NEUROSCIENCE,2019,13:10. |
| APA | Qin, Jiaolong.,Sui, Jing.,Ni, Huangjing.,Wang, Shuai.,Zhang, Fuquan.,...&Tian, Lin.(2019).The Shared and Distinct White Matter Networks Between Drug-Naive Patients With Obsessive-Compulsive Disorder and Schizophrenia.FRONTIERS IN NEUROSCIENCE,13,10. |
| MLA | Qin, Jiaolong,et al."The Shared and Distinct White Matter Networks Between Drug-Naive Patients With Obsessive-Compulsive Disorder and Schizophrenia".FRONTIERS IN NEUROSCIENCE 13(2019):10. |
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来源：自动化研究所
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