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Multiscale Stem Cell Technologies for Osteonecrosis of the Femoral Head

文献类型：期刊论文

作者Wang, Yi1,2; Ma, Xibo2,3; Chai, Wei1; Tian, Jie2,3
刊名STEM CELLS INTERNATIONAL
出版日期2019
页码13
ISSN号1687-966X
DOI10.1155/2019/8914569
通讯作者Chai, Wei(chaiwei301@163.com) ; Tian, Jie(tian@ieee.org)
英文摘要The last couple of decades have seen brilliant progress in stem cell therapies, including native, genetically modified, and engineered stem cells, for osteonecrosis of the femoral head (ONFH). In vitro studies evaluate the effect of endogenous or exogenous factor or gene regulation on osteogenic phenotype maintenance and/or differentiation towards osteogenic lineage. The preclinical and clinical outcomes accelerate the clinical translation. Bone marrow mesenchymal stem cells and adipose-derived stem cells have demonstrated better effects in the treatment of femoral head necrosis. Various materials have been used widely in the ONFH treatment in both preclinical and clinical trials. In a word, in vivo and multiscale efforts are expected to overcome obstacles in the approaches for treating ONFH and provide clinical relevance and commercial strategies in the future. Therefore, we will discuss the above aspects in this paper and present our opinions.
WOS关键词AUTOLOGOUS BONE-MARROW ; STEROID-ASSOCIATED OSTEONECROSIS ; AVASCULAR NECROSIS ; STROMAL CELLS ; OSTEOGENIC DIFFERENTIATION ; EARLY-STAGE ; INTRAVENOUS TRANSPLANTATION ; CORE DECOMPRESSION ; MONONUCLEAR-CELLS ; RECEPTOR-GAMMA
资助项目National Key Research Program of China[2016YFA0100900] ; National Key Research Program of China[2016YFA0100902] ; National Natural Science Foundation of China[81772320] ; National Natural Science Foundation of China[81227901] ; National Natural Science Foundation of China[815270805] ; National Natural Science Foundation of China[61231004] ; National Natural Science Foundation of China[81471739] ; National Natural Science Foundation of China[81472594] ; National Natural Science Foundation of China[81770781] ; Key Research Program of the Chinese Academy of Sciences[KGZD-EW-T03] ; Scientific Research and Equipment Development Project of Chinese Academy of Sciences[YZ201457] ; Beijing Natural Science Foundation[7174314]
WOS研究方向Cell Biology
语种英语
WOS记录号WOS:000456842700001
出版者HINDAWI LTD
资助机构National Key Research Program of China ; National Natural Science Foundation of China ; Key Research Program of the Chinese Academy of Sciences ; Scientific Research and Equipment Development Project of Chinese Academy of Sciences ; Beijing Natural Science Foundation
源URL[http://ir.ia.ac.cn/handle/173211/25315]  
专题自动化研究所_中国科学院分子影像重点实验室
通讯作者Chai, Wei; Tian, Jie
作者单位1.Chinese Peoples Liberat Army Gen Hosp, Dept Orthoped, Beijing 100853, Peoples R China
2.Chinese Acad Sci, Inst Automat, CAS Key Lab Mol Imaging, Beijing 100190, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式
GB/T 7714		 Wang, Yi,Ma, Xibo,Chai, Wei,et al. Multiscale Stem Cell Technologies for Osteonecrosis of the Femoral Head[J]. STEM CELLS INTERNATIONAL,2019:13.
APA Wang, Yi,Ma, Xibo,Chai, Wei,&Tian, Jie.(2019).Multiscale Stem Cell Technologies for Osteonecrosis of the Femoral Head.STEM CELLS INTERNATIONAL,13.
MLA Wang, Yi,et al."Multiscale Stem Cell Technologies for Osteonecrosis of the Femoral Head".STEM CELLS INTERNATIONAL (2019):13.

入库方式： OAI收割

来源：自动化研究所

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