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Core-Satellite Nanomedicines for in Vivo Real-Time Monitoring of Enzyme-Activatable Drug Release by Fluorescence and Photoacoustic Dual-Modal Imaging

文献类型：期刊论文

作者Li, Xianlei1,2; Bottini, Massimo1,4; Zhang, Luyao6; Zhang, Shuai7; Chen, Jing1; Zhang, Tingbin1; Liu, Lu1,2; Rosato, Nicola4; Ma, Xibo2,7; Shi, Xinghua2,5
刊名ACS NANO
出版日期2019
卷号13期号:1页码:176-186
ISSN号1936-0851
关键词core-satellite drug release in vivo nanomedicines computer simulation dual-modal imaging
DOI10.1021/acsnano.8b05136
通讯作者Wu, Yan(wuy@nanoctr.cn) ; Guo, Weisheng(tjuguoweisheng@126.com) ; Liang, Xing-Jie(liangxj@nanoctr.cn)
英文摘要It remains an unresolved challenge to achieve spatial and temporal monitoring of drug release from nano medicines (NMs) in vivo, which is of crucial importance in disease treatment. To tackle this issue, we constructed core-satellite ICG/DOX@Gel-CuS NMs, which consist of gelatin (Gel) nanoparticles (NPs) with payloads of near-infrared fluorochrome indocyanine green (ICG) and chemo-drug doxorubicin (DOX) and surrounding CuS NPs. The fluorescence of ICG was initially shielded by satellite CuS NPs within the intact ICG/DOX@Gel-CuS NMs and increased in proportion to the amount of DOX released from NMs in response to enzyme-activated NMs degradation. For more comprehensive understanding of the drug-release profile, a theoretical model derived from computer simulation was employed to reconstruct the enzyme-activatable drug release of the ICG/DOX@Gel-CuS NMs, which demonstrated the underlying kinetics functional relationship between the released DOX amount and recovered ICG fluorescence intensity. The kinetics of drug release in vivo was assessed by administrating ICG/DOX@Gel-CuS NMs both locally and systemically into MDA-MB-231 tumor-bearing mice. Upon accumulation of ICG/DOX@Gel-CuS NMs in the tumor, overexpressed enzymes triggered the degradation of the gelatin scaffold as well as the release of DOX and ICG, which can be visually depicted with the ICG fluorescence signal increasing only in the tumor area by fluorescence imaging. Additionally, the photoacoustic signal from CuS NPs was independent from the physical status of ICG/DOX@Gel-CuS NMs and hence was utilized for real-time NMs tracking. Thus, by taking advantage of the core satellite architecture and NMs degradability in tumor site, the DOX release profile of ICG/DOX@Gel-CuS NMs was monitored by fluorescence and photoacoustic dual-modal imaging in a real-time noninvasive manner.
WOS关键词ENHANCED PERMEABILITY ; MAGNETIC-RESONANCE ; POLYMERIC MICELLES ; SOLUTE DIFFUSION ; NANOPARTICLES ; DELIVERY ; MECHANISMS ; HYDROGELS ; GELATIN ; LESSONS
资助项目National Natural Science Foundation Key Projects[31630027] ; National Natural Science Foundation Key Projects[31430031] ; National Natural Science Foundation Key Projects[81601603] ; National Natural Science Foundation Key Projects[81773185] ; National Natural Science Foundation Key Projects[81471739] ; NSFC-DFG project[31761133013] ; National Distinguished Young Scholars grant[31225009] ; external cooperation program of the Chinese Academy of Science[121D11KYSB20160066] ; Strategic Priority Research Program of the Chinese Academy of Sciences[XDA09030301] ; National Key Research Program of China[2016YFA0100900] ; National Key Research Program of China[2016YFA0100902] ; NanOArt grant of the Mission Sustain ability of the University of Rome Tor Vergata
WOS研究方向Chemistry ; Science & Technology - Other Topics ; Materials Science
语种英语
出版者AMER CHEMICAL SOC
WOS记录号WOS:000456749900019
资助机构National Natural Science Foundation Key Projects ; NSFC-DFG project ; National Distinguished Young Scholars grant ; external cooperation program of the Chinese Academy of Science ; Strategic Priority Research Program of the Chinese Academy of Sciences ; National Key Research Program of China ; NanOArt grant of the Mission Sustain ability of the University of Rome Tor Vergata
源URL[http://ir.ia.ac.cn/handle/173211/25339]  
专题自动化研究所_模式识别国家重点实验室_生物识别与安全技术研究中心
通讯作者Wu, Yan; Guo, Weisheng; Liang, Xing-Jie
作者单位1.Natl Ctr Nanosci & Technol China, CAS Ctr Excellence Nanosci, CAS Key Lab Biomed Effects Nanomat & Nanosafety, 11 First North Rd, Beijing 100190, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Guangzhou Med Univ, Affiliated Hosp 2, Translat Med Ctr, State Key Lab Resp Dis, Guangzhou 510260, Guangdong, Peoples R China
4.Univ Roma Tor Vergata, Dept Expt Med & Surg, Via Montpellier 1, I-00133 Rome, Italy
5.Chinese Acad Sci, Natl Ctr Nanosci & Technol, CAS Ctr Excellence Nanosci, CAS Key Lab Nanosyst & Hierarchy Fabricat, Beijing 100190, Peoples R China
6.Chinese Acad Sci, Inst Mech, LNM, Beijing 100190, Peoples R China
7.Chinese Acad Sci, Inst Automat, CAS Key Lab Mol Imaging, Beijing 100190, Peoples R China
推荐引用方式
GB/T 7714		 Li, Xianlei,Bottini, Massimo,Zhang, Luyao,et al. Core-Satellite Nanomedicines for in Vivo Real-Time Monitoring of Enzyme-Activatable Drug Release by Fluorescence and Photoacoustic Dual-Modal Imaging[J]. ACS NANO,2019,13(1):176-186.
APA Li, Xianlei.,Bottini, Massimo.,Zhang, Luyao.,Zhang, Shuai.,Chen, Jing.,...&Liang, Xing-Jie.(2019).Core-Satellite Nanomedicines for in Vivo Real-Time Monitoring of Enzyme-Activatable Drug Release by Fluorescence and Photoacoustic Dual-Modal Imaging.ACS NANO,13(1),176-186.
MLA Li, Xianlei,et al."Core-Satellite Nanomedicines for in Vivo Real-Time Monitoring of Enzyme-Activatable Drug Release by Fluorescence and Photoacoustic Dual-Modal Imaging".ACS NANO 13.1(2019):176-186.

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来源：自动化研究所

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