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Altered brain functional network in children with type 1 Gaucher disease: a longitudinal graph theory-based study

文献类型：期刊论文

作者Zhang, Miao1; Wang, Shengpei2,3; Hu, Di1; Kang, Huiying1; Ouyang, Minhui4; Zhang, Yonghong5; Rao, Bo1; Huang, Hao4,6; Peng, Yun1
刊名NEURORADIOLOGY
出版日期2019
卷号61期号:1页码:63-70
关键词Gaucher disease Children Resting-state functional MRI Brain functional networks Graph theory
ISSN号0028-3940
DOI10.1007/s00234-018-2104-3
通讯作者Peng, Yun(ppengyun@yahoo.com)
英文摘要PurposePrevious studies have investigated the brain structural abnormalities in children with type I Gaucher disease (GD). The purpose of our study is to investigate the topological efficiency of the brain functional network in children with type 1 GD.MethodsTwenty-two children diagnosed with type 1 GD and 22 sex- and age-matched healthy controls (HCs) underwent resting-state functional MRI (rs-fMRI) examination. For longitudinal study, the GD patients underwent rs-fMRI examination again after 4.6years. Graph theoretical analysis was used to assess the brain network topological properties at the global and regional levels.ResultsCompared with the HCs, the children with type 1 GD showed a decreased efficiency in functional segregation with a decreased (normalized clustering coefficient). In addition, the balance between functional segregation and integration was disrupted with decreased small-worldness (sigma). At the regional level, the children with type 1 GD showed significantly decreased nodal degree and efficiency in the right precentral gyrus (PreCG.R) and left postcentral gyrus (PoCG.L). The significantly altered , sigma, and nodal degree in the PreCG.R and PoCG.L were negatively correlated with the disease duration. No significant alterations in the global and regional topological properties were identified in these patients over time.ConclusionCompared with that of the HCs, the efficiency of the brain functional network in the children with type 1 GD was disrupted, and regional involvement was located in motor- and sensory-related regions. The efficiency of the brain functional network in these patients remained stable over time.
WOS关键词CONNECTIVITY NETWORKS ; PERIPHERAL NEUROPATHY ; ORGANIZATION ; DIAGNOSIS ; TOPOLOGY
资助项目National Natural Science Foundation of China[81671651]
WOS研究方向Neurosciences & Neurology ; Radiology, Nuclear Medicine & Medical Imaging
语种英语
WOS记录号WOS:000456076500012
出版者SPRINGER
资助机构National Natural Science Foundation of China
源URL[http://ir.ia.ac.cn/handle/173211/25341]  
专题类脑智能研究中心_神经计算及脑机交互
通讯作者Peng, Yun
作者单位1.Capital Med Univ, Natl Ctr Childrens Hlth, Beijing Childrens Hosp, Dept Radiol, Beijing 100045, Peoples R China
2.Chinese Acad Sci, Inst Automat, Res Ctr Brain Inspired Intelligence, Beijing 100190, Peoples R China
3.Univ Chinese Acad Sci, Beijing, Peoples R China
4.Childrens Hosp Philadelphia, Dept Radiol, Philadelphia, PA 19104 USA
5.Capital Med Univ, Beijing Childrens Hosp, Natl Ctr Childrens Hlth, Hematol Oncol Ctr, Beijing 100045, Peoples R China
6.Univ Penn, Perelman Sch Med, Dept Radiol, Philadelphia, PA 19104 USA
推荐引用方式
GB/T 7714		 Zhang, Miao,Wang, Shengpei,Hu, Di,et al. Altered brain functional network in children with type 1 Gaucher disease: a longitudinal graph theory-based study[J]. NEURORADIOLOGY,2019,61(1):63-70.
APA Zhang, Miao.,Wang, Shengpei.,Hu, Di.,Kang, Huiying.,Ouyang, Minhui.,...&Peng, Yun.(2019).Altered brain functional network in children with type 1 Gaucher disease: a longitudinal graph theory-based study.NEURORADIOLOGY,61(1),63-70.
MLA Zhang, Miao,et al."Altered brain functional network in children with type 1 Gaucher disease: a longitudinal graph theory-based study".NEURORADIOLOGY 61.1(2019):63-70.

入库方式： OAI收割

来源：自动化研究所

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