Neoadjuvant nano-photothermal therapy used before operation effectively assists in surgery for breast cancer
文献类型：期刊论文
| 作者 | Yan, Hao1,2; Shang, Wenting3 ; Sun, Xiaodan1; Zhao, Lingyun1; Wang, Xiumei1; Zhang, Shuixing4; Xu, Nan1; Xu, Wanhai5; Tian, Jie3; Kang, Feiyu1,2
|
| 刊名 | NANOSCALE
 |
| 出版日期 | 2019-01-14 |
| 卷号 | 11期号:2页码:706-716 |
| ISSN号 | 2040-3364 |
| DOI | 10.1039/c8nr08109c |
| 通讯作者 | Xu, Wanhai(xuwanhai@163.com) ; Tian, Jie(jie.tian@ia.ac.cn) ; Kang, Feiyu(fykang@mail.tsinghua.edu.cn) |
| 英文摘要 | Nano-photothermal therapy (NPTT) has attracted increasing interest recently due to its high efficiency, excellent selectivity and non-ionizing radiation damage. Despite a tremendous amount of exciting pre-clinical results reported in the past few years, however, the further clinic application of NPTT is still difficult. To combine NPTT with clinical surgery more closely, novel multifunctional optical-magnetic nanosystems have been synthesized and applied for preoperative NPTT to assist in the follow-up surgery, termed "neoadjuvant NPTT". Remarkably, nanoparticles are mainly aggregated in the cytoplasm of tumor cells in vitro and largely accumulated in the tumor in vivo 24 h after injection. Under the guidance of tri-modality imaging, preoperative NPTT could shrink the tumor in a short time and make the boundary between the tumor and surrounding normal tissues clearer, which is conducive to subsequent surgery resection. Furthermore, the 50% survival rate is up to 50 days compared with 35 days for standard surgery, 31 days for PTT alone and 24 days for non-surgery groups. Therefore, NPTT can effectively assist in surgery used before operation. This study provides a new idea for the clinical transformation of NPTT in the future. |
| WOS关键词 | NANOPARTICLES ; CHEMOTHERAPY ; NANOSHELLS |
| 资助项目 | National Key Research and Development Program of China[2016YFB0700800] ; Intergovernmental Cooperation in Science and Technology[2016YFE0125300] ; NSFC[81172182] ; NSFC[81671829] ; fund of Key Laboratory of Advanced Materials of Ministry of Education[2017AML12] |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics |
| 语种 | 英语 |
| WOS记录号 | WOS:000455001600035 |
| 出版者 | ROYAL SOC CHEMISTRY |
| 资助机构 | National Key Research and Development Program of China ; Intergovernmental Cooperation in Science and Technology ; NSFC ; fund of Key Laboratory of Advanced Materials of Ministry of Education |
| 源URL | [http://ir.ia.ac.cn/handle/173211/25639]  |
| 专题 | 自动化研究所_中国科学院分子影像重点实验室 |
| 通讯作者 | Xu, Wanhai; Tian, Jie; Kang, Feiyu |
| 作者单位 | 1.Tsinghua Univ, Sch Mat Sci & Engn, State Key Lab New Ceram & Fine Proc, Beijing 100084, Peoples R China 2.Tsinghua Univ, Grad Sch Shenzhen, Engn Lab Functionalized Carbon Mat, Shenzhen 518055, Peoples R China 3.Chinese Acad Sci, Inst Automat, Key Lab Mol Imaging, Beijing 100190, Peoples R China 4.Jinan Univ, Affiliated Hosp 1, Dept Radiol, Guangzhou, Guangdong, Peoples R China 5.Harbin Med Univ, Hosp 4, Urol Surg Dept, Harbin 150001, Heilongjiang, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yan, Hao,Shang, Wenting,Sun, Xiaodan,et al. Neoadjuvant nano-photothermal therapy used before operation effectively assists in surgery for breast cancer[J]. NANOSCALE,2019,11(2):706-716. |
| APA | Yan, Hao.,Shang, Wenting.,Sun, Xiaodan.,Zhao, Lingyun.,Wang, Xiumei.,...&Kang, Feiyu.(2019).Neoadjuvant nano-photothermal therapy used before operation effectively assists in surgery for breast cancer.NANOSCALE,11(2),706-716. |
| MLA | Yan, Hao,et al."Neoadjuvant nano-photothermal therapy used before operation effectively assists in surgery for breast cancer".NANOSCALE 11.2(2019):706-716. |
入库方式： OAI收割
来源：自动化研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。