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Highly Erbium-Doped Nanoplatform with Enhanced Red Emission for Dual-Modal Optical-Imaging-Guided Photodynamic Therapy

文献类型：期刊论文

作者Feng, Miao1; Lv, Ruichan1; Xiao, Liyang1; Hu, Bo1; Zhu, Shouping1; He, Fei2; Yang, Piaoping2; Tian, Jie1,3
刊名INORGANIC CHEMISTRY
出版日期2018-12-03
卷号57期号:23页码:14594-14602
ISSN号0020-1669
DOI10.1021/acs.inorgchem.8b02257
通讯作者Lv, Ruichan(rclv@xidian.edu.cn) ; Yang, Piaoping(yangpiaoping@hrbeu.edu.cn) ; Tian, Jie(jie.tian@ia.ac.cn)
英文摘要Generally, luminescence quenching at high doping concentrations typically limits the concentration of doped ions in the lanthanide material to less than 0.05-20 mol %, and this is still a major hindrance in designing nanoplatforms with improved brightness. In this research, a nanoplatform capable of dual-modal imaging and synergetic antitumor cells therapy was designed. NaYF4:x%Er@NaXF4 (x = 5, 25, 50, and 100; X = Lu and Y) core@shell nanoparticles with Er3+ ion concentration up to 100 mol % were synthesized, and the luminescence properties under near-infrared (NIR) excitation were detected. The results show the strong coupled of surface and concentration quenching effects in upconversion nanoparticles (UCNP). Upconversion luminescence (UCL) and NIR-II emission intensity increased with negligible concentration quenching effect under 980 and 800 nm NIR lasers because of the growth of epitaxial shells. Therefore, the enhanced red luminescence transfers energy to photosensitizer ZnPc as the photodynamic therapy (PDT) agent for tumor inhibition efficacy.
WOS关键词UP-CONVERSION NANOPARTICLES ; ENERGY-TRANSFER ; LIGHT ; SHELL ; NANOCRYSTALS ; LUMINESCENCE ; SURFACE ; DESIGN ; NANOPHOSPHOR ; STRATEGY
资助项目Natural Science Foundation of China[NSFC 81227901] ; Natural Science Foundation of China[81772011] ; Natural Science Foundation of China[81801744] ; National Key R&D Program of China[2016YFC0102000] ; National Key R&D Program of China[2017YFA0205202] ; National Key R&D Program of China[2017YFA0205200] ; Fundamental Research Funds for the Central Universities[XJS17011] ; Fundamental Research Funds for the Central Universities[JBX181202]
WOS研究方向Chemistry
语种英语
WOS记录号WOS:000452344400019
出版者AMER CHEMICAL SOC
资助机构Natural Science Foundation of China ; National Key R&D Program of China ; Fundamental Research Funds for the Central Universities
源URL[http://ir.ia.ac.cn/handle/173211/25669]  
专题自动化研究所_中国科学院分子影像重点实验室
通讯作者Lv, Ruichan; Yang, Piaoping; Tian, Jie
作者单位1.Xidian Univ, Sch Life Sci & Technol, Engn Res Ctr Mol & Neuro Imaging, Minist Educ, Xian 710071, Shaanxi, Peoples R China
2.Harbin Engn Univ, Coll Mat Sci & Chem Engn, Key Lab Superlight Mat & Surface Technol, Minist Educ, Harbin 150001, Heilongjiang, Peoples R China
3.Chinese Acad Sci, Inst Automat, Key Lab Mol Imaging, Beijing 100190, Peoples R China
推荐引用方式
GB/T 7714		 Feng, Miao,Lv, Ruichan,Xiao, Liyang,et al. Highly Erbium-Doped Nanoplatform with Enhanced Red Emission for Dual-Modal Optical-Imaging-Guided Photodynamic Therapy[J]. INORGANIC CHEMISTRY,2018,57(23):14594-14602.
APA Feng, Miao.,Lv, Ruichan.,Xiao, Liyang.,Hu, Bo.,Zhu, Shouping.,...&Tian, Jie.(2018).Highly Erbium-Doped Nanoplatform with Enhanced Red Emission for Dual-Modal Optical-Imaging-Guided Photodynamic Therapy.INORGANIC CHEMISTRY,57(23),14594-14602.
MLA Feng, Miao,et al."Highly Erbium-Doped Nanoplatform with Enhanced Red Emission for Dual-Modal Optical-Imaging-Guided Photodynamic Therapy".INORGANIC CHEMISTRY 57.23(2018):14594-14602.

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来源：自动化研究所

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