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Topiramate and Metformin Are Effective Add-On Treatments in Controlling Antipsychotic-Induced Weight Gain: A Systematic Review and Network Meta-Analysis

文献类型：期刊论文

作者Zhuo, Chuanjun1,2,3,4,5,6; Xu, Yong4,5,6; Liu, Sha4,5,6; Li, Jing4,5,6; Zheng, Qishi7; Gao, Xiangyang8; Li, Shen3; Jing, Rixing9; Song, Xueqin10; Yue, Weihua11,12,13
刊名FRONTIERS IN PHARMACOLOGY
出版日期2018-11-28
卷号9页码:10
关键词antipsychotic-induced weight gain network meta-analysis pharmacological add-ons topiramate metformin
ISSN号1663-9812
DOI10.3389/fphar.2018.01393
通讯作者Zhuo, Chuanjun(chuanjunzhuotjmh@163.com) ; Yue, Weihua(dryue@bjmu.edu.cn) ; Zhou, Chunhua(zhouchunhua80@126.com)
英文摘要Background: Antipsychotic drugs may lead to side effects such as obesity, diabetes, dyslipidemia, and cardiovascular disease. The current systematic review and network meta-analysis analyzes and provides an update on the clinical performance of these add-ons in comparison to placebo on body weight and body mass index (BMI) reductions. Methods: A comprehensive literature search was performed on electronic databases: PubMed (1946-), Embase (1974-), Cochrane library (1992-), and OpenGrey (2000-) until 31 July 2018. Network meta-analyses, comparing the body weight change, BMI change and withdrawn due to adverse events of different pharmacological add-ons, was performed using a multivariate meta-regression model with random-effects, adopting a frequentist approach. To rank the prognosis for all add-ons, we used surface under the cumulative ranking (SUCRA) values. Outcomes: From 614 potential studies identified, 27 eligible studies (n = 1,349 subjects) were included. All the studies demonstrated low to moderate risk of bias. For the analysis of body weight change, all add-ons except Ranitidine showed significant weight reductions comparing to placebo. The effectiveness rank based on SUCRA results from highest to lowest was Sibutramine, Topiramate, Metformin, Reboxetine, Ranitidine, and placebo. A similar pattern was seen for BMI change. The analysis of safety outcome did not detect significantly increased withdrawn number from the add-ons. Current evidence showed relatively good tolerance and safety of using the pharmacological add-ons. Interpretation: Topiramate and Metformin are effective add-on treatments in controlling antipsychotic-induced weight gain, comparing to placebo. They are well tolerated in short-term period. Although Sibutramine has the highest rank of the effectiveness, its license has been withdrawn in many countries due to its adverse effects. Hence, Sibutramine should not be adopted to treat antipsychotic-induced weight gain.
WOS关键词PLACEBO-CONTROLLED TRIAL ; OLANZAPINE-TREATED PATIENTS ; AUTISM SPECTRUM DISORDER ; DOUBLE-BLIND ; BODY-WEIGHT ; METABOLIC DYSFUNCTION ; OPEN-LABEL ; 1ST-EPISODE SCHIZOPHRENIA ; OBESE-PATIENTS ; YOUNG-PEOPLE
资助项目Tianjin Health Bureau Foundation[2014KR02] ; National Natural Science Foundation of China[81871052] ; National Natural Science Foundation of China[81701326] ; National Natural Science Foundation of China[81571319] ; Key Projects of the Natural Science Foundation of Tianjin, China[17JCZDJC35700] ; National Key Research and Development Program of China[2016YFC1307004] ; Multidisciplinary Team for Cognitive Impairment of Shanxi Science and Technology Innovation Training Team[201705D131027]
WOS研究方向Pharmacology & Pharmacy
语种英语
WOS记录号WOS:000451647300001
出版者FRONTIERS MEDIA SA
资助机构Tianjin Health Bureau Foundation ; National Natural Science Foundation of China ; Key Projects of the Natural Science Foundation of Tianjin, China ; National Key Research and Development Program of China ; Multidisciplinary Team for Cognitive Impairment of Shanxi Science and Technology Innovation Training Team
源URL[http://ir.ia.ac.cn/handle/173211/25701]  
专题自动化研究所_模式识别国家重点实验室
通讯作者Zhuo, Chuanjun; Yue, Weihua; Zhou, Chunhua
作者单位1.Tianjin Med Univ, Tianjin Anding Hosp, Dept Psychiat & Morbid, Tianjin, Peoples R China
2.Jining Med Univ, Dept Psychiat, Jining, Peoples R China
3.Tianjin Med Univ, Dept Psychiat, Tianjin, Peoples R China
4.Shanxi Med Univ, Hosp 1, Clin Med Coll 1, Dept Psychiat, Taiyuan, Shanxi, Peoples R China
5.Shanxi Med Univ, Hosp 1, MDT Ctr Cognit Impairment & Sleep Disorders, Taiyuan, Shanxi, Peoples R China
6.Shanxi Med Univ, Minist Educ, Key Lab Cellular Physiol, Dept Neurobiol,Natl Key Disciplines, Taiyuan, Shanxi, Peoples R China
7.Singapore Clin Res Inst, Dept Epidemiol, Singapore, Singapore
8.Chinese Peoples Liberat Army Gen Hosp, Big Data Anal Ctr, Hlth Management Inst, Beijing, Peoples R China
9.Chinese Acad Sci, Inst Automat, China Natl Key Lab, Dept Pattern Recognit, Beijing, Peoples R China
10.Zhengzhou Univ, Affiliated Hosp 1, Dept Psychiat, Zhengzhou, Henan, Peoples R China
推荐引用方式
GB/T 7714		 Zhuo, Chuanjun,Xu, Yong,Liu, Sha,et al. Topiramate and Metformin Are Effective Add-On Treatments in Controlling Antipsychotic-Induced Weight Gain: A Systematic Review and Network Meta-Analysis[J]. FRONTIERS IN PHARMACOLOGY,2018,9:10.
APA Zhuo, Chuanjun.,Xu, Yong.,Liu, Sha.,Li, Jing.,Zheng, Qishi.,...&Upthegrove, Rachel.(2018).Topiramate and Metformin Are Effective Add-On Treatments in Controlling Antipsychotic-Induced Weight Gain: A Systematic Review and Network Meta-Analysis.FRONTIERS IN PHARMACOLOGY,9,10.
MLA Zhuo, Chuanjun,et al."Topiramate and Metformin Are Effective Add-On Treatments in Controlling Antipsychotic-Induced Weight Gain: A Systematic Review and Network Meta-Analysis".FRONTIERS IN PHARMACOLOGY 9(2018):10.

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