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Subdivisions of the posteromedial cortex in disorders of consciousness

文献类型：期刊论文

作者Cui, Yue1,2,3; Song, Ming1,2,3; Lipnicki, Darren M.4; Yang, Yi5; Ye, Chuyang1,2,3; Fan, Lingzhong1,2,3; Sui, Jing1,2,3,6,9; Jiang, Tianzi1,2,3,7,8,9; He, Jianghong5
刊名NEUROIMAGE-CLINICAL
出版日期2018
卷号20页码:260-266
关键词Default mode network Diffusion tensor imaging Disorders of consciousness Parcellation Parietal cortex Persistent vegetative state
ISSN号2213-1582
DOI10.1016/j.nicl.2018.07.025
通讯作者Jiang, Tianzi(jiangtz@nlpr.ia.ac.cn) ; He, Jianghong(he_jianghong@sina.cn)
英文摘要Evidence suggests that disruptions of the posteromedial cortex (PMC) and posteromedial corticothalamic connectivity contribute to disorders of consciousness (DOCs). While most previous studies treated the PMC as a whole, this structure is functionally heterogeneous. The present study investigated whether particular subdivisions of the PMC are specifically associated with DOCs. Participants were DOC patients, 21 vegetative state/unresponsive wakefulness syndrome (VS/UWS), 12 minimally conscious state (MCS), and 29 healthy controls. Individual PMC and thalamus were divided into distinct subdivisions by their fiber tractograpy to each other and default mode regions, and white matter integrity and brain activity between/within subdivisions were assessed. The thalamus was represented mainly in the dorsal and posterior portions of the PMC, and the white matter tracts connecting these subdivisions to the thalamus had less integrity in VS/UWS patients than in MCS patients and healthy controls. In addition, these tracts had less integrity in DOC patients who did not recover after 12 months than in patients who did. The structural substrates were validated by resting state fMRI finding impaired functional activity within these PMC subdivisions. This study is the first to show that tracts from dorsal and posterior subdivisions of the PMC to the thalamus contribute to DOCs.
WOS关键词DEFAULT MODE NETWORK ; CONNECTIVITY-BASED PARCELLATION ; TRAUMATIC BRAIN-INJURY ; FUNCTIONAL CONNECTIVITY ; VEGETATIVE STATE ; RESTING-STATE ; STRUCTURAL CONNECTIVITY ; CINGULATE CORTEX ; AXONAL INJURY ; RECOVERY
资助项目Natural Science Foundation of China[31771076] ; Natural Science Foundation of China[81771128] ; Natural Science Foundation of China[91432302] ; Natural Science Foundation of China[31620103905] ; Science Frontier Program of the Chinese Academy of Sciences[QYZDJ-SSW-SMC019] ; National Key R&D Program of China[2017YFA0105203] ; Beijing Municipal Science & Technology Commission[Z141107002514111] ; Beijing Municipal Science & Technology Commission[Z161100000216152] ; Beijing Municipal Science & Technology Commission[Z161100000216139] ; Guangdong Pearl River Talents Plan[2016ZT06S220]
WOS研究方向Neurosciences & Neurology
语种英语
WOS记录号WOS:000450799000029
出版者ELSEVIER SCI LTD
资助机构Natural Science Foundation of China ; Science Frontier Program of the Chinese Academy of Sciences ; National Key R&D Program of China ; Beijing Municipal Science & Technology Commission ; Guangdong Pearl River Talents Plan
源URL[http://ir.ia.ac.cn/handle/173211/25703]  
专题自动化研究所_脑网络组研究中心
通讯作者Jiang, Tianzi; He, Jianghong
作者单位1.Chinese Acad Sci, Inst Automat, Brainnetome Ctr, Beijing 100190, Peoples R China
2.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing 100190, Peoples R China
3.Univ Chinese Acad Sci, Beijing, Peoples R China
4.Univ New South Wales, Sch Psychiat, CHeBA Ctr Healthy Brain Ageing, Randwick, NSW 2031, Australia
5.PLA Army Gen Hosp, Dept Neurosurg, Beijing 100700, Peoples R China
6.Mind Res Network & Lovelace Biomed & Environm Res, Albuquerque, NM 87106 USA
7.Univ Elect Sci & Technol China, Sch Life Sci & Technol, Key Lab NeuroInformat, Minist Educ, Chengdu 610054, Sichuan, Peoples R China
8.Univ Queensland, Queensland Brain Inst, Brisbane, Qld 4072, Australia
9.Chinese Acad Sci, Inst Automat, Ctr Excellence Brain Sci & Intelligence Techn, Beijing 100190, Peoples R China
推荐引用方式
GB/T 7714		 Cui, Yue,Song, Ming,Lipnicki, Darren M.,et al. Subdivisions of the posteromedial cortex in disorders of consciousness[J]. NEUROIMAGE-CLINICAL,2018,20:260-266.
APA Cui, Yue.,Song, Ming.,Lipnicki, Darren M..,Yang, Yi.,Ye, Chuyang.,...&He, Jianghong.(2018).Subdivisions of the posteromedial cortex in disorders of consciousness.NEUROIMAGE-CLINICAL,20,260-266.
MLA Cui, Yue,et al."Subdivisions of the posteromedial cortex in disorders of consciousness".NEUROIMAGE-CLINICAL 20(2018):260-266.

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来源：自动化研究所

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