An integrated method for simultaneously determining 10 classes of per- and polyfluoroalkyl substances in one drop of human serum
文献类型：期刊论文
| 作者 | Gao, Ke; Fu, Jianjie ; Xue, Qiao; Li, Yili; Liang, Yong; Pan, Yuanyuan; Zhang, Aiqian; Jiang, Guibin
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| 刊名 | ANALYTICA CHIMICA ACTA
 |
| 出版日期 | 2018-01-25 |
| 卷号 | 999页码:76-86 |
| 关键词 | Online turboflow SPE Per-and poly-fluoroalkyl substances Fluorinated precursors Perfluoroalkyl phosphonates Polyfluoroalkyl phosphate esters SRM 1957 |
| ISSN号 | 0003-2670 |
| 文献子类 | Article |
| 英文摘要 | Per- and polyfluoroalkyl substances (PFASs) represent a group of synthetic chemicals, and they have quite different physicochemical properties, which result in difficulties of their simultaneous determination in a single injection. A sensitive, reliable, and fully automated method was developed for simultaneously detecting 10 classes of PFASs (total of 43) in human serum using online Turboflow SPE-UHPLC-MS/MS. This method provided high linearity of matrix-matched calibration standards (R > 0.99), excellent method limits of detection (MLODs) (0.013-0.089 ng mL(-1)). satisfactory matrix spiked recoveries (84.3-109%) and relative standard deviations (RSDs) (intra-day RSDs: 1.3-12.6%, inter-day RSDs: 1.7-13.8%, inter-week RSDs: 1.8-13.5%, inter-month RSDs: 3.1-12.4%), short analysis time (19 min per sample) and small sample amount requirement (25 mu L), which were suitable for large-scale epidemiologic studies. Moreover, the method provided the feasibility of real-time monitoring for the degradation kinetics of PFASs precursors both in vitro and in vivo. The quality of the present method was further verified by repetitive analysis of a standard reference material (SRM 1957), with the deviations of the targeted PFAS concentrations ranging from 1.9% to 14.2% (n = 5) between the detected and reference values. The present study also determined values for several PFASs in SRM 1957 other than those on the certificate, for the first time, such as N-EtFOSA, 6:2 Cl-PFESA, and PFBA. Finally, the established method was applied to detect PFASs in serum samples of 15 ordinary people and 15 occupational workers, and 6:2 FTSA was found as the dominant precursor. (C) 2017 Elsevier B.V. All rights reserved. |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/40874]  |
| 专题 | 生态环境研究中心_环境化学与生态毒理学国家重点实验室 |
| 推荐引用方式 GB/T 7714 | Gao, Ke,Fu, Jianjie,Xue, Qiao,et al. An integrated method for simultaneously determining 10 classes of per- and polyfluoroalkyl substances in one drop of human serum[J]. ANALYTICA CHIMICA ACTA,2018,999:76-86. |
| APA | Gao, Ke.,Fu, Jianjie.,Xue, Qiao.,Li, Yili.,Liang, Yong.,...&Jiang, Guibin.(2018).An integrated method for simultaneously determining 10 classes of per- and polyfluoroalkyl substances in one drop of human serum.ANALYTICA CHIMICA ACTA,999,76-86. |
| MLA | Gao, Ke,et al."An integrated method for simultaneously determining 10 classes of per- and polyfluoroalkyl substances in one drop of human serum".ANALYTICA CHIMICA ACTA 999(2018):76-86. |
入库方式： OAI收割
来源：生态环境研究中心
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