Antimony exposure and speciation in human biomarkers near an active mining area in Hunan, China
文献类型：期刊论文
| 作者 | Ye, Li; Qiu, Shixin; Li, Xinhai; Jiang, Yuxuan; Jing, Chuanyong |
| 刊名 | SCIENCE OF THE TOTAL ENVIRONMENT
 |
| 出版日期 | 2018-11-01 |
| 卷号 | 640页码:1-8 |
| 关键词 | Antimony Biomarker Dietary exposure Methylated Sb |
| ISSN号 | 0048-9697 |
| 文献子类 | Article |
| 英文摘要 | Antimony (Sb) exposure threatens human health. To identify human biomarkers for Sb exposure, we analyzed 480 environmental samples from an active Sb mining area in Hunan, China. Elevated Sb concentrations exceeding the reference level were detected in drinking water (70% of n = 83 total samples), foods (80%, n = 188), urine (95%, n = 63), saliva (44%, n = 48), hair (80%, n = 51) and nails (83%, n = 47). Drinking water contributed 85%-100% of the average daily dose (ADD) of Sb, and the total ADD (11.7 mu g/kg bodyweight/day) was up to thirty times higher than the oral reference dose (0.4 mu g/kg bodyweight/day) as recommended by USEPA. A positive correlation was found between ADD and Sb content in hair (p=0.02), but not in urine (p=0.051), saliva (p=0.52) or nails (p=0.85), suggesting that hair is the best non-invasive biomarker. Micro X-ray fluorescence analysis indicated that Sb is distributed in discrete spots in hair and nails, and Sb distribution is correlated with other metals. Methylated Sb species were predominant in urine (46%-100%) and saliva (74%-100%) in collected samples, implying that the human metabolic system adopts methylation as an effective pathway to detoxify and excrete Sb. (C) 2018 Elsevier B.V. All rights reserved. |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/40879]  |
| 专题 | 生态环境研究中心_环境化学与生态毒理学国家重点实验室 |
| 推荐引用方式 GB/T 7714 | Ye, Li,Qiu, Shixin,Li, Xinhai,et al. Antimony exposure and speciation in human biomarkers near an active mining area in Hunan, China[J]. SCIENCE OF THE TOTAL ENVIRONMENT,2018,640:1-8. |
| APA | Ye, Li,Qiu, Shixin,Li, Xinhai,Jiang, Yuxuan,&Jing, Chuanyong.(2018).Antimony exposure and speciation in human biomarkers near an active mining area in Hunan, China.SCIENCE OF THE TOTAL ENVIRONMENT,640,1-8. |
| MLA | Ye, Li,et al."Antimony exposure and speciation in human biomarkers near an active mining area in Hunan, China".SCIENCE OF THE TOTAL ENVIRONMENT 640(2018):1-8. |
入库方式： OAI收割
来源：生态环境研究中心
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