CdSe Quantum Dots Incurred Hemoglobin RNA Transcription Inhibition in Embryonic Erythroid Precursors and Compromised Embryonic Development in Mice under Low-Dose Exposure
文献类型：期刊论文
| 作者 | Wang, Zhe; Liu, Wei; Zhang, Shuping ; Zhang, Jie; Liu, Sijin
|
| 刊名 | ACS SUSTAINABLE CHEMISTRY & ENGINEERING
 |
| 出版日期 | 2018-03-01 |
| 卷号 | 6期号:3页码:4164-4173 |
| 关键词 | Quantum dots Fetal livers Globin mRNA transcription RNA polymerase Embryonic development |
| ISSN号 | 2168-0485 |
| 文献子类 | Article |
| 英文摘要 | Sustainable development of nanotechnology should comprise maximum benefits and minimum potential risks to the environment and human health. Despite quantum dots (QDs) being widely acknowledged as promising nanomaterials in various application fields, there are still knowledge gaps regarding their safe use in nanomedicine and their environmental health and safety. Given that previous investigations mostly elaborated on the direct effects of nanomaterials on cells and organs at high doses, little consideration has been taken to look into the transportation associated toxicity upon low-dose exposure to engineered nanomaterials. In the current study, we first uncovered that CdSe QDs did not elicit significant gross toxicity in mice upon acute and chronic low-dose exposure. Further, our chronic exposure results displayed that QD particles could accumulate in the embryonic hematopoietic organ fetal liver on embryonic day 14.5 (E14.5), leading to a great reduction of hemoglobin mRNA transcription in fetal liver cells. Mechanistic investigations revealed that the diminished globin RNA synthesis due to the significant inhibition on RNA polymerase activity, at least partially, accounted for hypoproduction of hemoglobin in embryonic erythroid precursors. Compromised embryonic erythropoiesis eventually resulted in embryonic developmental retardation upon chronic low-dose QD exposure. Of note, Cd ions at comparable doses did not manifest such effects as observed for QDs, ruling out a direct attribution of QD-induced effects to Cd ions. This study would open a new path to understand the potential impacts of QDs on susceptible objects, such as developing embryos, due to transportation-associated secondary low dose exposure. |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/40893]  |
| 专题 | 生态环境研究中心_环境化学与生态毒理学国家重点实验室 |
| 推荐引用方式 GB/T 7714 | Wang, Zhe,Liu, Wei,Zhang, Shuping,et al. CdSe Quantum Dots Incurred Hemoglobin RNA Transcription Inhibition in Embryonic Erythroid Precursors and Compromised Embryonic Development in Mice under Low-Dose Exposure[J]. ACS SUSTAINABLE CHEMISTRY & ENGINEERING,2018,6(3):4164-4173. |
| APA | Wang, Zhe,Liu, Wei,Zhang, Shuping,Zhang, Jie,&Liu, Sijin.(2018).CdSe Quantum Dots Incurred Hemoglobin RNA Transcription Inhibition in Embryonic Erythroid Precursors and Compromised Embryonic Development in Mice under Low-Dose Exposure.ACS SUSTAINABLE CHEMISTRY & ENGINEERING,6(3),4164-4173. |
| MLA | Wang, Zhe,et al."CdSe Quantum Dots Incurred Hemoglobin RNA Transcription Inhibition in Embryonic Erythroid Precursors and Compromised Embryonic Development in Mice under Low-Dose Exposure".ACS SUSTAINABLE CHEMISTRY & ENGINEERING 6.3(2018):4164-4173. |
入库方式： OAI收割
来源：生态环境研究中心
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