DEP and DBP induce cytotoxicity in mouse embryonic stem cells and abnormally enhance neural ectoderm development
文献类型：期刊论文
| 作者 | Jiang, Guibin ; Faiola, Francesco; Zhou, Qunfang; Yang, Renjun; Hu, Bowen; Liang, Shaojun; Liang, Shengxian; Yin, Nuoya
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| 刊名 | ENVIRONMENTAL POLLUTION
 |
| 出版日期 | 2018-05-01 |
| 卷号 | 236页码:21-32 |
| 关键词 | DEP DBP Embryonic stem cell Developmental neural toxicity Phthalate |
| ISSN号 | 0269-7491 |
| 文献子类 | Article |
| 英文摘要 | Diethyl phthalate (DEP) and dibutyl phthalate (DBP) are two typical small phthalate esters, extensively used in personal care and consumer products. Although previous studies have linked phthalate esters to several health issues, it is still unclear whether they can affects the early stages of embryonic development. In this study, we evaluated the early developmental neurotoxicity as well as the cytotoxicity of DEP and DBP, using mouse embryonic stem cells (mESCs). Our results showed that both DEP and DBP could decrease mESC viability in a dose-dependent manner. Moreover, while DBP could activate the caspase-3/7 enzymes and cause cell membrane damage as well as intracellular ROS accumulation, interestingly DEP treatment only showed stimulation of ROS production. In addition, DEP and DBP treatment at non-cytotoxic concentrations, abnormally altered the expression levels of several vitally important regulators of embryo development. For instance, neural ectoderm markers, such as Pax6, Nestin, Sox1 and Sox3, were significantly up-regulated upon DEP and DBP exposure. In conclusion, our work suggests a potential developmental toxicity of DEP and DBP on mammals, especially for neural ectoderm specification. Our findings help better understand the association between health problems and DEP/DBP exposure and most significantly remind us of the importance of additional health risk tests for these two largely used chemicals. (C) 2018 Elsevier Ltd. All rights reserved. |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/40911]  |
| 专题 | 生态环境研究中心_环境化学与生态毒理学国家重点实验室 |
| 推荐引用方式 GB/T 7714 | Jiang, Guibin,Faiola, Francesco,Zhou, Qunfang,et al. DEP and DBP induce cytotoxicity in mouse embryonic stem cells and abnormally enhance neural ectoderm development[J]. ENVIRONMENTAL POLLUTION,2018,236:21-32. |
| APA | Jiang, Guibin.,Faiola, Francesco.,Zhou, Qunfang.,Yang, Renjun.,Hu, Bowen.,...&Yin, Nuoya.(2018).DEP and DBP induce cytotoxicity in mouse embryonic stem cells and abnormally enhance neural ectoderm development.ENVIRONMENTAL POLLUTION,236,21-32. |
| MLA | Jiang, Guibin,et al."DEP and DBP induce cytotoxicity in mouse embryonic stem cells and abnormally enhance neural ectoderm development".ENVIRONMENTAL POLLUTION 236(2018):21-32. |
入库方式： OAI收割
来源：生态环境研究中心
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