Design and synthesis of selenazole-substituted ritonavir analogs
文献类型：期刊论文
| 作者 | Liu, Jun; Zhao, Chuanfang; Qiao, Junfei; Du, Yuguo |
| 刊名 | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
 |
| 出版日期 | 2018-08-01 |
| 卷号 | 28期号:14页码:2379-2381 |
| 关键词 | Selenazole Ritonavir Antiviral Protease inhibitor One-pot reaction |
| ISSN号 | 0960-894X |
| 文献子类 | Article |
| 英文摘要 | With the help of Surflex-Dock calculation, two ritonavir analogs in which one thioazole unit was replaced by selenazole have been designed and synthesized. The key selenazole structure was constructed from beta-azido diselenide through a cascade diselenide cleavage/selenocarbonylation/Staudinger reduction/aza-Wittig reaction and a following MnO2 oxidation. The accordingly prepared compounds exhibited good anti-HIV-1 (IIIB) activities comparable to that of the original ritonavir, as well as the positive SI values. |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/40912]  |
| 专题 | 生态环境研究中心_环境化学与生态毒理学国家重点实验室 |
| 推荐引用方式 GB/T 7714 | Liu, Jun,Zhao, Chuanfang,Qiao, Junfei,et al. Design and synthesis of selenazole-substituted ritonavir analogs[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2018,28(14):2379-2381. |
| APA | Liu, Jun,Zhao, Chuanfang,Qiao, Junfei,&Du, Yuguo.(2018).Design and synthesis of selenazole-substituted ritonavir analogs.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,28(14),2379-2381. |
| MLA | Liu, Jun,et al."Design and synthesis of selenazole-substituted ritonavir analogs".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 28.14(2018):2379-2381. |
入库方式： OAI收割
来源：生态环境研究中心
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