Dioxin induces expression of hsa-miR-146b-5p in human neuroblastoma cells
文献类型：期刊论文
| 作者 | Sha, Rui; Zhao, Bin; Xu, Li; Chen, Yangsheng; Wang, Lingyun; Xia, Yingjie; Li, Yunping; Xie, Heidi Q.; Xu, Tuan |
| 刊名 | JOURNAL OF ENVIRONMENTAL SCIENCES
 |
| 出版日期 | 2018 |
| 卷号 | 63页码:260-267 |
| 关键词 | 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) MicroRNA Acetylcholinesterase (AChE) Neuron Transcription regulation Post-transcriptional regulation |
| ISSN号 | 1001-0742 |
| 文献子类 | Article |
| 英文摘要 | Dioxin can cause a series of neural toxicological effects. MicroRNAs (miRs) play important roles in regulating nervous systemfunction andmediating cellular responses to environmental pollutants, such as dioxin. Hsa-miR-146b-5p appears to be involved in neurodegenerative diseases and brain tumors. However, little is known about effects of dioxin on the expression of hsa-miR-146b-5p. We found that the hsa-miR-146b-5p expression and its promoter activity were significantly increased in dioxin treated SK-N-SH cells, a human-derived neuroblastoma cell line. Potential roles of hsa-miR-146b-5p in mediating neural toxicological effects of dioxin may be due to the regulation of certain target genes. We further confirmed that hsa-miR-146b-5p significantly suppressed acetylcholinesterase (AChE) activity and targeted the 3'-untranslated region of the AChE T subunit, which has been down-regulated in dioxin treated SK-N-SH cells. Functional bioinformatic analysis showed that the known and predicted target genes of hsa-miR-146b-5p were involved in some brain functions or cyto-toxicities related to known dioxin effects, including synapse transmission, in which AChE may serve as a responsive gene for mediating the effect. (C) 2017 The Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences. Published by Elsevier B.V. |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/40921]  |
| 专题 | 生态环境研究中心_环境化学与生态毒理学国家重点实验室 |
| 推荐引用方式 GB/T 7714 | Sha, Rui,Zhao, Bin,Xu, Li,et al. Dioxin induces expression of hsa-miR-146b-5p in human neuroblastoma cells[J]. JOURNAL OF ENVIRONMENTAL SCIENCES,2018,63:260-267. |
| APA | Sha, Rui.,Zhao, Bin.,Xu, Li.,Chen, Yangsheng.,Wang, Lingyun.,...&Xu, Tuan.(2018).Dioxin induces expression of hsa-miR-146b-5p in human neuroblastoma cells.JOURNAL OF ENVIRONMENTAL SCIENCES,63,260-267. |
| MLA | Sha, Rui,et al."Dioxin induces expression of hsa-miR-146b-5p in human neuroblastoma cells".JOURNAL OF ENVIRONMENTAL SCIENCES 63(2018):260-267. |
入库方式： OAI收割
来源：生态环境研究中心
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