中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
Distinct Iron Deposition Profiles of Liver Zones in Various Models with Iron Homeostasis Disorders

文献类型:期刊论文

作者Song, Haoyang; Zhang, Shuping; Sun, Xia; Liu, Jing; Wu, Yakun; Guo, Wenli; Wang, Fudi; Ou, Xiaojuan; Cong, Min; Jin, Erhu
刊名ADVANCED SCIENCE
出版日期2018-11-01
卷号5期号:11页码:-
关键词iron deficiency iron deposition iron homeostasis iron overload liver zones
ISSN号2198-3844
文献子类Article
英文摘要Determination of iron accumulation is crucial in diagnosing the occurrence and progression of many liver- and iron-related diseases. Thus far, little is known about the profiles of iron deposition in different liver zones, particularly under conditions with disordered iron homeostasis. Here, uneven iron distribution in livers of patients with hereditary hemochromatosis (HH) is uncovered, showing the region with the highest iron concentration near the entrance site of the portal vein and hepatic artery in contrast to the sites with the lowest iron concentration close to the distal edge. Distinct iron distribution profiles are also found throughout liver zones in wild-type mice and various mouse models with iron metabolism disorders, including hemochromatosis (Hfe(-/-)), iron deficiency, and inflammation. Of note, similar findings observed in HH patients are further demonstrated in Hfe(-/-) mice. Moreover, the zones with greater iron accumulation appear to be more sensitive to iron changes, e.g., there is iron increase upon iron overload and iron loss in response to iron deficiency. Mechanistic investigation manifests that these differential iron changes in liver zones are subjected to the regulation by the hepcidin-ferroportin axis. Additionally, the data corroborate the reliability of magnetic resonance imaging (MRI) in recognizing the differential iron deposition profiles among liver zones.
源URL[http://ir.rcees.ac.cn/handle/311016/40925]  
专题生态环境研究中心_环境化学与生态毒理学国家重点实验室
推荐引用方式
GB/T 7714
Song, Haoyang,Zhang, Shuping,Sun, Xia,et al. Distinct Iron Deposition Profiles of Liver Zones in Various Models with Iron Homeostasis Disorders[J]. ADVANCED SCIENCE,2018,5(11):-.
APA Song, Haoyang.,Zhang, Shuping.,Sun, Xia.,Liu, Jing.,Wu, Yakun.,...&Liu, Sijin.(2018).Distinct Iron Deposition Profiles of Liver Zones in Various Models with Iron Homeostasis Disorders.ADVANCED SCIENCE,5(11),-.
MLA Song, Haoyang,et al."Distinct Iron Deposition Profiles of Liver Zones in Various Models with Iron Homeostasis Disorders".ADVANCED SCIENCE 5.11(2018):-.

入库方式: OAI收割

来源:生态环境研究中心

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