Elevated 8-oxo-7,8-dihydro-2 '-deoxyguanosine in genome of T24 bladder cancer cells induced by halobenzoquinones
文献类型：期刊论文
| 作者 | Xu, Tian; Yin, Junfa ; Chen, Shaokun; Zhang, Dapeng; Wang, Hailin
|
| 刊名 | JOURNAL OF ENVIRONMENTAL SCIENCES
 |
| 出版日期 | 2018 |
| 卷号 | 63页码:133-139 |
| 关键词 | Halobenzoquinones Reactive oxygen species Oxidative DNA damage 8-Oxo-7,8-dihydro-2 ' deoxyguanosine (8-oxodG) |
| ISSN号 | 1001-0742 |
| 文献子类 | Article |
| 英文摘要 | Halobenzoquinones (HBQs) are an emerging class of halogenated disinfection byproducts (DBPs) in drinking water, which raised public concerns due to potential carcinogenic effects to human bladder. Our previous work demonstrated that HBQs and hydrogen peroxide (H2O2) together generated oxidative DNA damage via a metal-independent and intercalationenhanced oxidation mechanism in vitro. This study further investigated the efficiency of various HBQs to induce oxidative DNA damage in T24 bladder cancer cells. Compared with T24 cells without treatment (3.1 lesions per 106 dG), the level of 8-oxo-7,8-dihydro2'-deoxyguanosine (8-oxodG) significantly increased by 1.4, 3.2, 8.8, and 9.2 times after treatment with tetrabromo-1,4-benzoquinone (TBBQ), terachloro-1,4-benzoquinone (TCBQ), 2,6-dichloro-1,4-benzoquinone (2,6-DCBQ) and 2,5-dichloro-1,4-benzoquinone (2,5-DCBQ) for 24 hr, respectively. Interestingly, we found that the oxidative potency of HBQs in T24 cells (2,5-DCBQ approximate to 2,6-DCBQ > TCBQ > TBBQ) is inconsistent with that of in vitro dsDNA oxidation (TCBQ > TBBQ > 2,5-DCBQ > 2,6-DCBQ), suggesting HBQs induce oxidative lesions in cellular genomic DNA probably involved with a complex mechanism. (C) 2017 The Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences. Published by Elsevier B.V. |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/40936]  |
| 专题 | 生态环境研究中心_环境化学与生态毒理学国家重点实验室 |
| 推荐引用方式 GB/T 7714 | Xu, Tian,Yin, Junfa,Chen, Shaokun,et al. Elevated 8-oxo-7,8-dihydro-2 '-deoxyguanosine in genome of T24 bladder cancer cells induced by halobenzoquinones[J]. JOURNAL OF ENVIRONMENTAL SCIENCES,2018,63:133-139. |
| APA | Xu, Tian,Yin, Junfa,Chen, Shaokun,Zhang, Dapeng,&Wang, Hailin.(2018).Elevated 8-oxo-7,8-dihydro-2 '-deoxyguanosine in genome of T24 bladder cancer cells induced by halobenzoquinones.JOURNAL OF ENVIRONMENTAL SCIENCES,63,133-139. |
| MLA | Xu, Tian,et al."Elevated 8-oxo-7,8-dihydro-2 '-deoxyguanosine in genome of T24 bladder cancer cells induced by halobenzoquinones".JOURNAL OF ENVIRONMENTAL SCIENCES 63(2018):133-139. |
入库方式： OAI收割
来源：生态环境研究中心
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