Evaluation of the early developmental neural toxicity of F-53B, as compared to PFOS, with an in vitro mouse stem cell differentiation model
文献类型：期刊论文
| 作者 | Yin, Nuoya; Yang, Renjun; Liang, Shaojun; Liang, Shengxian; Hu, Bowen; Ruan, Ting; Faiola, Francesco |
| 刊名 | CHEMOSPHERE
 |
| 出版日期 | 2018-08-01 |
| 卷号 | 204页码:109-118 |
| ISSN号 | 0045-6535 |
| 关键词 | F-53B Perfluorooctane sulfonate (PFOS) Developmental neural toxicity Embryonic stem cells (ESCs) Neural differentiation Neuroectoderm |
| 文献子类 | Article |
| 英文摘要 | F-53B, as an alternative to the persistent organic pollutant perfluorooctane sulfonate (PFOS), is amply used in the electric plating industry. F-53B and PFOS have similar physicochemical, biochemical and physiological properties, due to the similarity in their chemical structure. Thus, they may also possess similar toxicities. Although epidemiological studies and in vivo assays have shown that prenatal exposure to PFOS may impair the development of the nervous system, toxicity data for F-53B are still scarce. In this study, we employed an embryonic stem cell (ESC) in vitro differentiation system, to detect the potential developmental neural toxicity of F-53B and PFOS, at human exposure relevant doses. We demonstrated that during early mouse ESC (mESC) neural differentiation, F-538 and PFOS disrupted the expression of neural marker genes and affected the morphology of the differentiated cells. However, the very same treatments did not cause any cytotoxic effects. In conclusion, our ESC in vitro differentiation system was able to prove for the first time that F-53B and PFOS at human exposure relevant concentrations, could alter the expression of differentiation biomarkers, indicating a potential developmental neural toxicity. Based on our findings, it is reasonable to deduce that excessive exposure to F-53B and PFOS may cause severe dysfunctions during early stages of embryo development. (C) 2018 Elsevier Ltd. All rights reserved. |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/40939]  |
| 专题 | 生态环境研究中心_环境化学与生态毒理学国家重点实验室 |
| 推荐引用方式 GB/T 7714 | Yin, Nuoya,Yang, Renjun,Liang, Shaojun,et al. Evaluation of the early developmental neural toxicity of F-53B, as compared to PFOS, with an in vitro mouse stem cell differentiation model[J]. CHEMOSPHERE,2018,204:109-118. |
| APA | Yin, Nuoya.,Yang, Renjun.,Liang, Shaojun.,Liang, Shengxian.,Hu, Bowen.,...&Faiola, Francesco.(2018).Evaluation of the early developmental neural toxicity of F-53B, as compared to PFOS, with an in vitro mouse stem cell differentiation model.CHEMOSPHERE,204,109-118. |
| MLA | Yin, Nuoya,et al."Evaluation of the early developmental neural toxicity of F-53B, as compared to PFOS, with an in vitro mouse stem cell differentiation model".CHEMOSPHERE 204(2018):109-118. |
入库方式： OAI收割
来源：生态环境研究中心
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