How Entanglement of Different Physicochemical Properties Complicates the Prediction of in Vitro and in Vivo Interactions of Gold Nanoparticles
文献类型：期刊论文
| 作者 | Xu, Ming; Soliman, Mahmoud G.; Sun, Xing; Pelaz, Beatriz; Feliu, Neus; Parak, Wolfgang J.; Liu, Sijin |
| 刊名 | ACS NANO
 |
| 出版日期 | 2018-10-01 |
| 卷号 | 12期号:10页码:10104-10113 |
| 关键词 | gold nanoparticles physicochemical properties prediction hierarchical cluster analysis |
| ISSN号 | 1936-0851 |
| 文献子类 | Article |
| 英文摘要 | The physicochemical properties of a set of 21 different gold nanoparticles (spherical and rod-shaped nanoparticles (NPs) of different diameters with three different surface coatings) were studied. Protein corona formation, in vitro uptake, effect on cell viability and proliferation, and in vivo biodistribution of these NPs were determined. The relation of the results of the different NPs was analyzed by hierarchical cluster analysis, which will tell which NPs have the most similar physicochemical properties and biological effects, without having to specify individual physicochemical parameters. The results show that the physicochemical properties of gold nanoparticles (Au NPs) are mainly accounted for by their hydrodynamic diameter and their zeta-potential. The formation of the protein corona is determined by the pH-dependence of their zeta-potential. While several reports found that in vitro uptake and in vivo biodistribution of NPs are correlated to individual physicochemical parameters, e.g., size, shape, or surface chemistry, such direct dependence in the investigated multidimensional set of NPs was not found in our study. This most likely is due to entanglement of the different parameters, which complicates the prediction of the biological effect of NPs in case multiple physicochemical properties are simultaneously varied. The in vitro uptake and in vivo biodistribution of NPs seem to be not directly driven by the protein corona, but the physicochemical properties determine as well the corona as they influence in vitro/in vivo behaviors, and thus the effect of the protein corona would be rather indirect. |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/40958]  |
| 专题 | 生态环境研究中心_环境化学与生态毒理学国家重点实验室 |
| 推荐引用方式 GB/T 7714 | Xu, Ming,Soliman, Mahmoud G.,Sun, Xing,et al. How Entanglement of Different Physicochemical Properties Complicates the Prediction of in Vitro and in Vivo Interactions of Gold Nanoparticles[J]. ACS NANO,2018,12(10):10104-10113. |
| APA | Xu, Ming.,Soliman, Mahmoud G..,Sun, Xing.,Pelaz, Beatriz.,Feliu, Neus.,...&Liu, Sijin.(2018).How Entanglement of Different Physicochemical Properties Complicates the Prediction of in Vitro and in Vivo Interactions of Gold Nanoparticles.ACS NANO,12(10),10104-10113. |
| MLA | Xu, Ming,et al."How Entanglement of Different Physicochemical Properties Complicates the Prediction of in Vitro and in Vivo Interactions of Gold Nanoparticles".ACS NANO 12.10(2018):10104-10113. |
入库方式： OAI收割
来源：生态环境研究中心
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