Induction of oxidative stress and sensitization of cancer cells to paclitaxel by gold nanoparticles with different charge densities and hydrophobicities
文献类型：期刊论文
| 作者 | Sun, Hainan; Liu, Yin; Bai, Xue; Zhou, Xiaofei; Zhou, Hongyu; Liu, Sijin; Yan, Bing |
| 刊名 | JOURNAL OF MATERIALS CHEMISTRY B
 |
| 出版日期 | 2018-03-21 |
| 卷号 | 6期号:11页码:1633-1639 |
| ISSN号 | 2050-750X |
| 文献子类 | Article |
| 英文摘要 | An elevated reactive oxygen species (ROS) level leads to cellular oxidative stress, which has long been associated with diseases, such as cancer. Thus, the understanding and appropriate manipulation of cellular oxidative stress are needed for disease treatment. It has been reported that nanoparticles induce oxidative stress in human cells through different pathways. However, how the physicochemical properties of nanoparticles perturb cellular oxidative stress remains unclear. In this paper, we explored the effects of the positive/negative charge density and hydrophobicity of gold nanoparticles (GNPs) on the induction of oxidative stress and related mechanisms. In multiple human cell lines, we found that only the positive charge density and hydrophobicity of nanoparticles were correlated with the induction of cellular oxidative stress. Hydrophobic nanoparticles generated oxidative stress mainly through NADPH oxidase activation while positively charged nanoparticles generated it through perturbations of the mitochondria and modulation of intracellular Ca2+ concentration. Furthermore, nanoparticle-induced oxidative stress sensitized paclitaxel-induced cancer cell killing by 200%. These findings provided unequivocal structural parameters for the design of future nanomedicine and biocompatible nanocarriers. |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/40967]  |
| 专题 | 生态环境研究中心_环境化学与生态毒理学国家重点实验室 |
| 推荐引用方式 GB/T 7714 | Sun, Hainan,Liu, Yin,Bai, Xue,et al. Induction of oxidative stress and sensitization of cancer cells to paclitaxel by gold nanoparticles with different charge densities and hydrophobicities[J]. JOURNAL OF MATERIALS CHEMISTRY B,2018,6(11):1633-1639. |
| APA | Sun, Hainan.,Liu, Yin.,Bai, Xue.,Zhou, Xiaofei.,Zhou, Hongyu.,...&Yan, Bing.(2018).Induction of oxidative stress and sensitization of cancer cells to paclitaxel by gold nanoparticles with different charge densities and hydrophobicities.JOURNAL OF MATERIALS CHEMISTRY B,6(11),1633-1639. |
| MLA | Sun, Hainan,et al."Induction of oxidative stress and sensitization of cancer cells to paclitaxel by gold nanoparticles with different charge densities and hydrophobicities".JOURNAL OF MATERIALS CHEMISTRY B 6.11(2018):1633-1639. |
入库方式： OAI收割
来源：生态环境研究中心
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。