Intranasal administration of tetrabromobisphenol A bis(2-hydroxyethyl ether) induces neurobehavioral changes in neonatal Sprague Dawley rats
文献类型：期刊论文
| 作者 | Liu, Qian S.; Liu, Na; Sun, Zhendong; Zhou, Qunfang; Jiang, Guibin
|
| 刊名 | JOURNAL OF ENVIRONMENTAL SCIENCES
 |
| 出版日期 | 2018 |
| 卷号 | 63页码:76-86 |
| 关键词 | TBBPA derivatives Intranasal administration Neurobehavorial test Histopathological observation Microarray analysis |
| ISSN号 | 1001-0742 |
| 文献子类 | Article |
| 英文摘要 | Tetrabromobisphenol A (TBBPA) and its derivatives are now being highly concerned due to their emerging environmental occurrence and deleterious effects on non-target organisms. Considering the potential neurotoxicity of TBBPA derivatives which has been demonstrated in vitro, what could happen in vivo is worthy of being studied. Tetrabromobisphenol A bis(2-hydroxyethyl ether) (TBBPA-BHEE), a representative TBBPA derivative, was selected for a 21-day exposure experiment on neonatal Sprague Dawley (SD) rats through intranasal administration. The neurobehavioral, histopathological changes, and differentially expressed genes based on RNA microarray were investigated to evaluate the neurological effects of this chemical. The results indicated that TBBPA-BHEE exposure significantly compromised the motor co-ordination performance and the locomotor activities (p < 0.05). The neurobehavioral phenotype could be attributed to the obvious histopathological changes in both cerebrum and cerebellum, such as neural cell swelling, microglial activation and proliferation. A total of 911 genes were up-regulated, whereas 433 genes were down-regulated. Gene set enrichment analysis showed multiple signaling pathways, including ubiquitin-mediated proteolysis and wingless-int (Wnt) signaling pathway etc. were involved due to TBBPA-BHEE exposure. The gene ontology enrichment analysis showed the basic cellular function and the neurological processes like synaptic transmissionwere influenced. The toxicological effects of TBBPA-BHEE observed in this study suggested the potential neuronal threaten from unintended exposure, which would be of great value in the biosafety evaluation of TBBPA derivatives. (C) 2017 The Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences. Published by Elsevier B. V. |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/40972]  |
| 专题 | 生态环境研究中心_环境化学与生态毒理学国家重点实验室 |
| 推荐引用方式 GB/T 7714 | Liu, Qian S.,Liu, Na,Sun, Zhendong,et al. Intranasal administration of tetrabromobisphenol A bis(2-hydroxyethyl ether) induces neurobehavioral changes in neonatal Sprague Dawley rats[J]. JOURNAL OF ENVIRONMENTAL SCIENCES,2018,63:76-86. |
| APA | Liu, Qian S.,Liu, Na,Sun, Zhendong,Zhou, Qunfang,&Jiang, Guibin.(2018).Intranasal administration of tetrabromobisphenol A bis(2-hydroxyethyl ether) induces neurobehavioral changes in neonatal Sprague Dawley rats.JOURNAL OF ENVIRONMENTAL SCIENCES,63,76-86. |
| MLA | Liu, Qian S.,et al."Intranasal administration of tetrabromobisphenol A bis(2-hydroxyethyl ether) induces neurobehavioral changes in neonatal Sprague Dawley rats".JOURNAL OF ENVIRONMENTAL SCIENCES 63(2018):76-86. |
入库方式： OAI收割
来源：生态环境研究中心
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