Method to build 2,4-substituted selenazole from beta-azido diselenide and carboxylic acid: A formal synthesis of selenazofurin
文献类型：期刊论文
| 作者 | Du, Yuguo; Liu, Yi; Qiao, Junfei |
| 刊名 | TETRAHEDRON
 |
| 出版日期 | 2018-06-14 |
| 卷号 | 74期号:24页码:3061-3068 |
| ISSN号 | 0040-4020 |
| 文献子类 | Article |
| 英文摘要 | A novel approach for the synthesis of 2,4-disubstituted selenazoles using carboxylic acids (or anhydrides) and beta-azido diselenide was achieved via a one-pot cascade formation of selenazoline (Staudinger reduction/diselenide cleavage/selenocarbonylation/aza-Wittig reaction) and a following MnO2-promoted oxidation. This method offers excellent substrate flexibility, and its valuable application is exemplified by an efficient total synthesis of Selenazofurin which exhibited good antitumor activities against K562 and A549 cells. (C) 2018 Elsevier Ltd. All rights reserved. |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/40980]  |
| 专题 | 生态环境研究中心_环境化学与生态毒理学国家重点实验室 |
| 推荐引用方式 GB/T 7714 | Du, Yuguo,Liu, Yi,Qiao, Junfei. Method to build 2,4-substituted selenazole from beta-azido diselenide and carboxylic acid: A formal synthesis of selenazofurin[J]. TETRAHEDRON,2018,74(24):3061-3068. |
| APA | Du, Yuguo,Liu, Yi,&Qiao, Junfei.(2018).Method to build 2,4-substituted selenazole from beta-azido diselenide and carboxylic acid: A formal synthesis of selenazofurin.TETRAHEDRON,74(24),3061-3068. |
| MLA | Du, Yuguo,et al."Method to build 2,4-substituted selenazole from beta-azido diselenide and carboxylic acid: A formal synthesis of selenazofurin".TETRAHEDRON 74.24(2018):3061-3068. |
入库方式： OAI收割
来源：生态环境研究中心
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