Mitochondrial damage mediated by ROS incurs bronchial epithelial cell apoptosis upon ambient PM2.5 exposure
文献类型：期刊论文
| 作者 | Su, Ruijun; Jin, Xiaoting; Xue, Bin; Zhou, Qunfang; Li, Zhuoyu |
| 刊名 | JOURNAL OF TOXICOLOGICAL SCIENCES
 |
| 出版日期 | 2018 |
| 卷号 | 43期号:2019-01-03页码:101-111 |
| 关键词 | Particular matter (PM2.5) Mitochondria ROS Bronchial epithelial cells Apoptosis |
| ISSN号 | 0388-1350 |
| 文献子类 | Article |
| 英文摘要 | Mitochondria can be used as important biomarkers of pollutants on human health, and fine particulate matter (PM2.5) has been documented to cause respiratory damage. However, current studies about the relationship between PM2.5 and mitochondria in respiratory tract are limited and warrant further detailed investigations. Hence, the study was aimed to evaluate effects of PM2.5 on mitochondrial structure, investigate the link between PM2.5-induced mitochondrial disorder and respiratory damage, and delineate the possible mechanisms using both in vitro and in vivo models. PM2.5 exposure resulted in damage of mitochondrial structure, including mitochondrial dynamic, DNA biogenesis and morphological alteration 16HBE cells. Furthermore, PM(2.5)elevated ROS formation. However, DPI and NAC (inhibitor of ROS) in supplement restored PM2.5-induced mitochondrial disorder. PM,,also contributed to the 16HBE cells apoptosis via mitochondrial pathway. Additionally, the results coincided with the in vivo data which were obtained from bronchial tissues of SD rats exposed to PM2.5 for 30 days. Collectively, this study uncovers that PM2.5 leads to the disorder of mitochondrial structure via ROS generation, and then results in respiratory damage. It provides further understanding about the detrimental effect of PM on respiratory damage, and reveals a mechanistic basis for preventing outcomes in polluted environments. |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/40984]  |
| 专题 | 生态环境研究中心_环境化学与生态毒理学国家重点实验室 |
| 推荐引用方式 GB/T 7714 | Su, Ruijun,Jin, Xiaoting,Xue, Bin,et al. Mitochondrial damage mediated by ROS incurs bronchial epithelial cell apoptosis upon ambient PM2.5 exposure[J]. JOURNAL OF TOXICOLOGICAL SCIENCES,2018,43(2019-01-03):101-111. |
| APA | Su, Ruijun,Jin, Xiaoting,Xue, Bin,Zhou, Qunfang,&Li, Zhuoyu.(2018).Mitochondrial damage mediated by ROS incurs bronchial epithelial cell apoptosis upon ambient PM2.5 exposure.JOURNAL OF TOXICOLOGICAL SCIENCES,43(2019-01-03),101-111. |
| MLA | Su, Ruijun,et al."Mitochondrial damage mediated by ROS incurs bronchial epithelial cell apoptosis upon ambient PM2.5 exposure".JOURNAL OF TOXICOLOGICAL SCIENCES 43.2019-01-03(2018):101-111. |
入库方式： OAI收割
来源：生态环境研究中心
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