Non-cytotoxic nanomolar concentrations of bisphenol A induce human mesenchymal stem cell adipogenesis and osteogenesis
文献类型：期刊论文
| 作者 | Faiola, Francesco; Yin, Nuoya; Dong, Hengzhi; Yao, Xinglei; Liu, Shuyu |
| 刊名 | ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
 |
| 出版日期 | 2018-11-30 |
| 卷号 | 164页码:448-454 |
| 关键词 | Bisphenol A (BPA) Human mesenchymal stem cells (hMSCs) Adipogenesis Osteogenesis Metabolic diseases Obesity |
| ISSN号 | 0147-6513 |
| 文献子类 | Article |
| 英文摘要 | Bisphenol A (BPA) is a typical endocrine disrupting chemical with extensive applications, and has been correlated with various hazardous health effects, including obesity and other metabolic-related diseases. Human mesenchymal stem cells (hMSCs), due to their abilities to differentiate into adipocytes and osteoblasts, can be a good in vitro model to assess chemical-dependent toxicity on adipogenesis or osteogenesis. Here, we employed hMSCs as an evaluation system to assess BPA-related effects on cell viability, oxidative stress induction, self-renewal, and differentiation. Our results revealed that low concentrations (1 and 10 nM) of BPA did not impair cell proliferation nor self-renewal capacity, but stimulated adipogenesis and osteogenesis. Our findings support the concern of BPA contributing to the epidemic of obesity, and also reveal its underlying toxicity on osteogenesis. |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/41000]  |
| 专题 | 生态环境研究中心_环境化学与生态毒理学国家重点实验室 |
| 推荐引用方式 GB/T 7714 | Faiola, Francesco,Yin, Nuoya,Dong, Hengzhi,et al. Non-cytotoxic nanomolar concentrations of bisphenol A induce human mesenchymal stem cell adipogenesis and osteogenesis[J]. ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY,2018,164:448-454. |
| APA | Faiola, Francesco,Yin, Nuoya,Dong, Hengzhi,Yao, Xinglei,&Liu, Shuyu.(2018).Non-cytotoxic nanomolar concentrations of bisphenol A induce human mesenchymal stem cell adipogenesis and osteogenesis.ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY,164,448-454. |
| MLA | Faiola, Francesco,et al."Non-cytotoxic nanomolar concentrations of bisphenol A induce human mesenchymal stem cell adipogenesis and osteogenesis".ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY 164(2018):448-454. |
入库方式： OAI收割
来源：生态环境研究中心
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