Perfluorohexadecanoic acid increases paracellular permeability in endothelial cells through the activation of plasma kallikrein-kinin system
文献类型：期刊论文
| 作者 | Jiang, Guibin ; Liu, Qian S.; Hao, Fang; Sun, Zhendong; Long, Yanmin; Zhou, Qunfang
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| 刊名 | CHEMOSPHERE
 |
| 出版日期 | 2018 |
| 卷号 | 190页码:191-200 |
| 关键词 | Per- and polyfluoroalkyl substances Kallikrein-kinin system Endothelial cells Paracellular permeability Adherens junctions Vascular endothelial cadherin |
| ISSN号 | 0045-6535 |
| 文献子类 | Article |
| 英文摘要 | Per- and polyfluoroalkyl substances (PFASs) are ubiquitous and high persistent in human blood, thus potentially inducing a myriad of deleterious consequences. Plasma kallikrein-kinin system (MS), which physiologically regulates vascular permeability, is vulnerable to exogenous stimulators, like PFASs with long-chain alkyl backbone substituted by electronegative fluorine. The study on the interactions of PFASs with the KKS and the subsequent effects on vascular permeability would be helpful to illustrate how the chemicals penetrate the biological vascular barriers to reach different tissues. In present study, three representative PFASs, including perfluorooctane sulfonic acid (PFOS), perfluorooctanoic acid (PFOA) and perfluorohexadecanoic acid (PFHxDA), were investigated for their effects on the activation of the KKS, paracellular permeability in human retina endothelial cells (HRECs) and integrity of the adherens junctions. In contrast to either PFOS or PFOA, PFHxDA efficiently triggered KKS activation in a concentration-dependent manner based on protease activity assays. The plasma activated by PFHxDA significantly increased paracellular permeability of HRECs through the degradation of adherens junctions. As evidenced by the antagonistic effect of aprotinin, PFHxDA-involved effects on vascular permeability were mediated by KKS activation. The results herein firstly revealed the mechanistic pathway for PFHxDA induced effects on vascular endothelial cells. Regarding the possible structure related activities of the chemicals, this finding would be of great help in the risk assessment of PFASs. (C) 2017 Elsevier Ltd. All rights reserved. |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/41010]  |
| 专题 | 生态环境研究中心_环境化学与生态毒理学国家重点实验室 |
| 推荐引用方式 GB/T 7714 | Jiang, Guibin,Liu, Qian S.,Hao, Fang,et al. Perfluorohexadecanoic acid increases paracellular permeability in endothelial cells through the activation of plasma kallikrein-kinin system[J]. CHEMOSPHERE,2018,190:191-200. |
| APA | Jiang, Guibin,Liu, Qian S.,Hao, Fang,Sun, Zhendong,Long, Yanmin,&Zhou, Qunfang.(2018).Perfluorohexadecanoic acid increases paracellular permeability in endothelial cells through the activation of plasma kallikrein-kinin system.CHEMOSPHERE,190,191-200. |
| MLA | Jiang, Guibin,et al."Perfluorohexadecanoic acid increases paracellular permeability in endothelial cells through the activation of plasma kallikrein-kinin system".CHEMOSPHERE 190(2018):191-200. |
入库方式： OAI收割
来源：生态环境研究中心
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