Polyfluorinated iodine alkanes regulated distinct breast cancer cell progression through binding with estrogen receptor alpha or beta isoforms
文献类型：期刊论文
| 作者 | Zhou, Qunfang; Song, Wenting; Liu, Qian S.; Sun, Zhendong; Yang, Xiaoxi; Jiang, Guibin
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| 刊名 | ENVIRONMENTAL POLLUTION
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| 出版日期 | 2018-08-01 |
| 卷号 | 239页码:300-307 |
| 关键词 | Polyfluorinated iodine alkanes Estrogen receptor isoforms Breast cancer cells Cell proliferation Cell cycle distribution |
| ISSN号 | 0269-7491 |
| 文献子类 | Article |
| 英文摘要 | Polyfluorinated iodine alkanes (PFIs) are a kind of emerging chemicals with endocrine disrupting effects. Based on the different binding preferences of PFIs to estrogen receptor alpha and beta isoforms (ER alpha and beta), two representative PFIs, dodecafluoro-1,6-diiodohexane (PFHxDI) and tridecafluorohexyl iodide (PFHx1), were selected to evaluate their effects on the proliferation of two kinds of breast cancer cells with different ER alpha/beta expression levels, MCF-7 and T47D. The cell viability assay showed PFHxDI could cause higher cellular toxicity than did PFHxI in both MCF-7 and T47D. MCF-7 with relatively higher ER alpha/beta expression ratio was more vulnerable to the cytotoxic treatments of PFHxI and PFHxDI when compared with T47D cells with relatively lower ER alpha/beta expression ratio. EdU incorporation and cell cycle analysis revealed that, similar to 17 beta-estrodiol (E-2), non-cytotoxic levels of PFHxDI could significantly promote the proliferation of MCF-7 by increasing cell population at S phase (p < 0.01), while T47D proliferation was not influenced by PFHxI exposure due to cell cycle arrest at G2/M phase. The cellular responses caused by estrogenic PFIs were dominantly mediated by their preferential binding affinities for ER isoforms, which would be helpful in the accurate assessment for their potential influences on the breast cancer progression. (C) 2018 Elsevier Ltd. All rights reserved. |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/41013]  |
| 专题 | 生态环境研究中心_环境化学与生态毒理学国家重点实验室 |
| 推荐引用方式 GB/T 7714 | Zhou, Qunfang,Song, Wenting,Liu, Qian S.,et al. Polyfluorinated iodine alkanes regulated distinct breast cancer cell progression through binding with estrogen receptor alpha or beta isoforms[J]. ENVIRONMENTAL POLLUTION,2018,239:300-307. |
| APA | Zhou, Qunfang,Song, Wenting,Liu, Qian S.,Sun, Zhendong,Yang, Xiaoxi,&Jiang, Guibin.(2018).Polyfluorinated iodine alkanes regulated distinct breast cancer cell progression through binding with estrogen receptor alpha or beta isoforms.ENVIRONMENTAL POLLUTION,239,300-307. |
| MLA | Zhou, Qunfang,et al."Polyfluorinated iodine alkanes regulated distinct breast cancer cell progression through binding with estrogen receptor alpha or beta isoforms".ENVIRONMENTAL POLLUTION 239(2018):300-307. |
入库方式： OAI收割
来源：生态环境研究中心
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