中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
Preliminary test on the distribution, hydrolyzation and excretion of aluminum dialkyl phosphinate flame retardants in rats

文献类型:期刊论文

作者Li, Lisha; Liu, Yuchen; Liu, Jiyan; Liu, Jingfu; Niu, Yumin; Liang, Yong
刊名ENVIRONMENTAL POLLUTION
出版日期2018-11-01
卷号242页码:1998-2004
关键词Aluminum methylcyclohexyl phosphinic Distribution Excretion Hydrolysis
ISSN号0269-7491
文献子类Article
英文摘要Aluminum dialkyl phosphinates (ADPs) are a promising class of chemicals offering superior flame retardance. However, knowledge on their behavior in vivo is scarce. Hydrolysis has been suggested as one of the major routes of environmental degradation of ADPs. Herein, aluminum methylcyclohexyl phosphinic (AMHP), a kind of ADPs with industrial production in China, and its hydrolysate methyl cyclohexyl phosphinic acid (MHPA) were continuously exposed to Sprague Dawley (SD) rats for 28 days in this study. The same ratio of MHPA in organs to serum and the same daily excretion of MHPA were observed for AMHP exposure group and MHPA exposure group, suggesting the hydrolysis of AMHP in vivo. The hydrolysis of AMHP to MHPA was further confirmed by in vitro simulated human gastric intestinal juice. Therefore, both AMHP and MHPA distributed in liver, kidney and even brain in the form of MHPA. More than 80% of AMHP and MHPA could be excreted by feces and urine. Feces are the main route of excretion of AMHP and MHPA. The denseness of the inflammatory cell in the hepatic portal area and biochemical indexes showed the obvious dose-effect relationship. However, the toxicity of AMHP and MHPA was quite low even with exposure level up to 100 mg/kg dw/day. The low cumulative ability and mild toxicity indicated AMHP as a promising substitute for brominated flame retardant. (C) 2018 Published by Elsevier Ltd.
源URL[http://ir.rcees.ac.cn/handle/311016/41016]  
专题生态环境研究中心_环境化学与生态毒理学国家重点实验室
推荐引用方式
GB/T 7714
Li, Lisha,Liu, Yuchen,Liu, Jiyan,et al. Preliminary test on the distribution, hydrolyzation and excretion of aluminum dialkyl phosphinate flame retardants in rats[J]. ENVIRONMENTAL POLLUTION,2018,242:1998-2004.
APA Li, Lisha,Liu, Yuchen,Liu, Jiyan,Liu, Jingfu,Niu, Yumin,&Liang, Yong.(2018).Preliminary test on the distribution, hydrolyzation and excretion of aluminum dialkyl phosphinate flame retardants in rats.ENVIRONMENTAL POLLUTION,242,1998-2004.
MLA Li, Lisha,et al."Preliminary test on the distribution, hydrolyzation and excretion of aluminum dialkyl phosphinate flame retardants in rats".ENVIRONMENTAL POLLUTION 242(2018):1998-2004.

入库方式: OAI收割

来源:生态环境研究中心

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