YY1 Positively Regulates Transcription by Targeting Promoters and Super-Enhancers through the BAF Complex in Embryonic Stem Cells
文献类型：期刊论文
| 作者 | Wang, Jia; Wu, Xingui; Wei, Chao; Huang, Xin ; Ma, Qian; Huang, Xiaona; Faiola, Francesco; Guallar, Diana; Fidalgo, Miguel; Huang, Tingyuan
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| 刊名 | STEM CELL REPORTS
 |
| 出版日期 | 2018-04-10 |
| 卷号 | 10期号:4页码:1324-1339 |
| ISSN号 | 2213-6711 |
| 文献子类 | Article |
| 英文摘要 | Yin Yang 1 (YY1) regulates early embryogenesis and adult tissue formation. However, the role of YY1 in stem cell regulation remains unclear. YY1 has a Polycomb group (PcG) protein-dependent role in mammalian cells. The PcG-independent functions of YY1 are also reported, although their underlying mechanism is still undefined. This paper reports the role of YY1 and BAF complex in the OCT4-mediated pluripotency network in mouse embryonic stem cells (mESCs). The interaction between YY1 and BAF complex promotes mESC proliferation and pluripotency. Knockdown of Yy1 or Smarca4, the core component of the BAF complex, downregulates pluripotency markers and upregulates several differentiation markers. Moreover, YY1 enriches at both promoter and super-enhancer regions to stimulate transcription. Thus, this study elucidates the role of YY1 in regulating pluripotency through its interaction with OCT4 and the BAF complex and the role of BAF complex in integrating YY1 into the core pluripotency network. |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/41083]  |
| 专题 | 生态环境研究中心_环境化学与生态毒理学国家重点实验室 |
| 推荐引用方式 GB/T 7714 | Wang, Jia,Wu, Xingui,Wei, Chao,et al. YY1 Positively Regulates Transcription by Targeting Promoters and Super-Enhancers through the BAF Complex in Embryonic Stem Cells[J]. STEM CELL REPORTS,2018,10(4):1324-1339. |
| APA | Wang, Jia.,Wu, Xingui.,Wei, Chao.,Huang, Xin.,Ma, Qian.,...&Ding, Junjun.(2018).YY1 Positively Regulates Transcription by Targeting Promoters and Super-Enhancers through the BAF Complex in Embryonic Stem Cells.STEM CELL REPORTS,10(4),1324-1339. |
| MLA | Wang, Jia,et al."YY1 Positively Regulates Transcription by Targeting Promoters and Super-Enhancers through the BAF Complex in Embryonic Stem Cells".STEM CELL REPORTS 10.4(2018):1324-1339. |
入库方式： OAI收割
来源：生态环境研究中心
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