Metabolism Distribution and Effect of Thiamethoxam after Oral Exposure in Mongolian Racerunner (Eremias argus)
文献类型：期刊论文
| 作者 | Guo, Baoyuan; Wang, Yinghuan ; Zhang, Yang; Xu, Peng; Li, Wei
|
| 刊名 | JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
 |
| 出版日期 | 2018-07-18 |
| 卷号 | 66期号:28页码:7376-7383 |
| 关键词 | Eremias argus thiamethoxam metabolism distribution |
| ISSN号 | 0021-8561 |
| 文献子类 | Article |
| 英文摘要 | Systematic evaluation of the metabolism, distribution, and effect of thiamethoxam in Mongolian racerunner (Eremias argus) was carried out after oral exposure. HPLC equipped with Q Exactive focus was used for identification and concentration analysis of thiamethoxam and its metabolites. Percutaneous and urine excretions were the primary ways for the elimination of thiamethoxam and its metabolites, and the limiting factor was urine output. Demethylated thiamethoxam and clothianidin were the main metabolites of thiamethoxam in lizards. CYP3A4, CYP3A7, and CYP2C9 played a crucial role in the metabolism process. Aldehyde oxidase only dominated the nitro-reduction process of demethylated thiamethoxam and clothianidin. Glutathione S-transferase might be related to the clearance process of thiamethoxam and its metabolites. The findings indicated that thiamethoxam might pose potential carcinogenic and hepatic injury risk to lizards. The results enrich and supplement the knowledge of the environmental fate of thiamethoxam in reptiles. |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/41277]  |
| 专题 | 生态环境研究中心_中国科学院环境生物技术重点实验室 |
| 推荐引用方式 GB/T 7714 | Guo, Baoyuan,Wang, Yinghuan,Zhang, Yang,et al. Metabolism Distribution and Effect of Thiamethoxam after Oral Exposure in Mongolian Racerunner (Eremias argus)[J]. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,2018,66(28):7376-7383. |
| APA | Guo, Baoyuan,Wang, Yinghuan,Zhang, Yang,Xu, Peng,&Li, Wei.(2018).Metabolism Distribution and Effect of Thiamethoxam after Oral Exposure in Mongolian Racerunner (Eremias argus).JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,66(28),7376-7383. |
| MLA | Guo, Baoyuan,et al."Metabolism Distribution and Effect of Thiamethoxam after Oral Exposure in Mongolian Racerunner (Eremias argus)".JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 66.28(2018):7376-7383. |
入库方式： OAI收割
来源：生态环境研究中心
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