Molecular Toxicity of Metal Oxide Nanoparticles in Danio rerio
文献类型：期刊论文
| 作者 | Li, Shiguo; Hou, Jing; Liu, Haigiang; Wang, Luyao; Duan, Linshuai; Wang, Xiangke |
| 刊名 | ENVIRONMENTAL SCIENCE & TECHNOLOGY
 |
| 出版日期 | 2018-07-17 |
| 卷号 | 52期号:14页码:7996-8004 |
| ISSN号 | 0013-936X |
| 文献子类 | Article |
| 英文摘要 | Metal oxide nanoparticles can exert adverse effects on humans and aquatic organisms; however, their toxic mechanisms are still unclear. We investigated the toxic effects and mechanisms of copper oxide, zinc oxide, and nickel oxide nanoparticles in Danio rerio using microarray analysis and the comet assay. Copper oxide nanoparticles were more lethal than the other metal oxide nanoparticles. Gene ontology analysis of genes that were differentially expressed following exposure to all three metal oxide nanoparticles showed that the nanoparticles mainly affected nucleic acid metabolism in the nucleus via alterations in nucleic acid binding. KEGG analysis classified the differentially expressed genes to the genotoxicity-related pathways "cell cycle", "Fanconi anemia", "DNA replication", and "homologous recombination". The toxicity of metal oxide nanoparticles may be related to impairments in DNA synthesis and repair, as well as to increased production of reactive oxygen species. |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/41281]  |
| 专题 | 生态环境研究中心_中国科学院环境生物技术重点实验室 |
| 推荐引用方式 GB/T 7714 | Li, Shiguo,Hou, Jing,Liu, Haigiang,et al. Molecular Toxicity of Metal Oxide Nanoparticles in Danio rerio[J]. ENVIRONMENTAL SCIENCE & TECHNOLOGY,2018,52(14):7996-8004. |
| APA | Li, Shiguo,Hou, Jing,Liu, Haigiang,Wang, Luyao,Duan, Linshuai,&Wang, Xiangke.(2018).Molecular Toxicity of Metal Oxide Nanoparticles in Danio rerio.ENVIRONMENTAL SCIENCE & TECHNOLOGY,52(14),7996-8004. |
| MLA | Li, Shiguo,et al."Molecular Toxicity of Metal Oxide Nanoparticles in Danio rerio".ENVIRONMENTAL SCIENCE & TECHNOLOGY 52.14(2018):7996-8004. |
入库方式： OAI收割
来源：生态环境研究中心
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