Oral and dermal diflubenzuron exposure causes a hypothalamic-pituitary-thyroid (HPT) axis disturbance in the Mongolian racerunner (Eremias argus)
文献类型：期刊论文
| 作者 | Chang, Jing; Wang, Huili ; Xu, Peng; Guo, Baoyuan; Li, Jianzhong; Wang, Yinghuan; Li, Wei
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| 刊名 | ENVIRONMENTAL POLLUTION
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| 出版日期 | 2018 |
| 卷号 | 232页码:338-346 |
| 关键词 | Diflubenzuron The hypothalamic-pituitary-thyroid axis Thyroid hormones Dermal Oral |
| ISSN号 | 0269-7491 |
| 文献子类 | Article |
| 英文摘要 | Diflubenzuron (DFB) is a potential endocrine-disrupting chemical. However, its thyroid endocrine effect on reptiles has not been reported. In this study, immature lizards (Eremias argus) were exposed to 20 mg kg(-1) DFB once a week for 42 days through oral or dermal routes. Their body weight, plasma thyroid hormone levels, thyroid gland histology and the transcription of hypothalamic-pituitary-thyroid (HPT) axis-related genes in different tissues were assessed to explore the effects of DFB on the HPT axis of lizards. The body weight decreased significantly only after the dermal exposure to DFB. Triiodothyronine (T3) to thyroxine (14) ratio in the male plasma also significantly increased after the dermal exposure. After oral exposure, the activity of thyroid gland was positively related to the thyroid hormone levels. Furthermore, the alterations in thyroid hormone levels affected the HPT axis-related gene expression, which was tissue dependent and sexually selected. The thyroid hormone receptor genes (tr alpha and tr beta) in the brain and thyroid were more sensitive to oral exposure. However, only the dermal treatment affected the tr alpha, tr beta and type 2 deiodinase (dio2) genes in the male liver. These results suggest that DFB exposure caused sex-specific changes in the thyroid function of lizards, and the dermal treatment may be an important route for the risk assessment of reptiles. (C) 2017 Elsevier Ltd. All rights reserved. |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/41285]  |
| 专题 | 生态环境研究中心_中国科学院环境生物技术重点实验室 |
| 推荐引用方式 GB/T 7714 | Chang, Jing,Wang, Huili,Xu, Peng,et al. Oral and dermal diflubenzuron exposure causes a hypothalamic-pituitary-thyroid (HPT) axis disturbance in the Mongolian racerunner (Eremias argus)[J]. ENVIRONMENTAL POLLUTION,2018,232:338-346. |
| APA | Chang, Jing.,Wang, Huili.,Xu, Peng.,Guo, Baoyuan.,Li, Jianzhong.,...&Li, Wei.(2018).Oral and dermal diflubenzuron exposure causes a hypothalamic-pituitary-thyroid (HPT) axis disturbance in the Mongolian racerunner (Eremias argus).ENVIRONMENTAL POLLUTION,232,338-346. |
| MLA | Chang, Jing,et al."Oral and dermal diflubenzuron exposure causes a hypothalamic-pituitary-thyroid (HPT) axis disturbance in the Mongolian racerunner (Eremias argus)".ENVIRONMENTAL POLLUTION 232(2018):338-346. |
入库方式： OAI收割
来源：生态环境研究中心
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