Stereoselective degradation and thyroid endocrine disruption of lambda-cyhalothrin in lizards (Eremias argus) following oral exposure
文献类型：期刊论文
| 作者 | Li, Wei ; Xu, Peng; Xu, Yuanyuan; Hao, Weiyu; Chang, Jing; Wang, Huili; Li, Jianzhong
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| 刊名 | ENVIRONMENTAL POLLUTION
 |
| 出版日期 | 2018 |
| 卷号 | 232页码:300-309 |
| 关键词 | Pyrethroid pesticide Eremias argus Hypothalamus-pituitary-thyroid axis Enantioselectivity |
| ISSN号 | 0269-7491 |
| 文献子类 | Article |
| 英文摘要 | The disturbance of the thyroid system and elimination of chiral pyrethroid pesticides with respect to enantioselectivity in reptiles have so far received limited attention by research. In this study, bioaccumulation, thyroid gland lesions, thyroid hormone levels, and hypothalamus-pituitary-thyroid axis related gene expression in male Eremias argus were investigated after three weeks oral administration of lambda-cyhalothrin (LCT) enantiomers. In the lizard liver, the concentration of LCT was negatively correlated with the metabolite-3-phenoxybenzoic acid (PBA) level during 21 days of exposure. (+)-LCT exposure induced a higher thyroid follicular epithelium height than (-)-LCT exposure. The thyroxine levels were increased in both treated groups while only (+)-LCT exposure induced a significant change in the triiodothyronine (T3) level. In addition, the expressions of hypothalamus-pituitary-thyroid axis related genes including thyroid hormone receptors (trs), deiodinases (dios), uridinediphosphate glucuronosyltransferase (udp), and sulfotransferase (suit) were up-regulated after exposure to the two enantiomers. (+)-LCT treatment resulted in higher expression of trs and (-)-LCT exposure led to greater stimulation of dios in the liver, which indicated PBA-induced antagonism on thyroid hormone receptors and LCT-induced disruption of thyroxine (T4) deiodination. The results suggest the (-)-LCT exposure causes higher residual level in lizard liver while induces less disruption on lizard thyroid activity than (+)-LCT. (C) 2017 Elsevier Ltd. All rights reserved. |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/41296]  |
| 专题 | 生态环境研究中心_中国科学院环境生物技术重点实验室 |
| 推荐引用方式 GB/T 7714 | Li, Wei,Xu, Peng,Xu, Yuanyuan,et al. Stereoselective degradation and thyroid endocrine disruption of lambda-cyhalothrin in lizards (Eremias argus) following oral exposure[J]. ENVIRONMENTAL POLLUTION,2018,232:300-309. |
| APA | Li, Wei.,Xu, Peng.,Xu, Yuanyuan.,Hao, Weiyu.,Chang, Jing.,...&Li, Jianzhong.(2018).Stereoselective degradation and thyroid endocrine disruption of lambda-cyhalothrin in lizards (Eremias argus) following oral exposure.ENVIRONMENTAL POLLUTION,232,300-309. |
| MLA | Li, Wei,et al."Stereoselective degradation and thyroid endocrine disruption of lambda-cyhalothrin in lizards (Eremias argus) following oral exposure".ENVIRONMENTAL POLLUTION 232(2018):300-309. |
入库方式： OAI收割
来源：生态环境研究中心
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